Post-Operative Pain Relief with Zynrelef vs Periarticular Injections in Robot-Assisted Knee Replacement
Official title: Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study
Run by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · NCT07430085 · Data updated 2026-11-12
This study tests whether the Zynrelef extended-release periarticular injection can reduce pain and opioid use after robot-assisted total knee arthroplasty compared with standard periarticular injections.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 89 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Academic / other |
| Locations | 1 site (Cranberry Township, Pennsylvania) |
| Status | Recruiting |
| Started | September 3, 2026 |
| Main results expected | January 31, 2028 |
| Study ends | February 28, 2028 |
| Registry record updated | October 28, 2026 |
| Trial ID | NCT07430085 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–89 with unilateral knee OA undergoing RATKA at AHN facilities who consent to participate.
✕Probably not a fit
Patients with high BMI, recent contralateral TKA, or NSAID/local anesthetic hypersensitivity may not benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective cohort with two arms evaluating pain outcomes and postoperative opioid consumption after robot-assisted total knee arthroplasty (RATKA). Patients who undergo RATKA at Allegheny Health Network facilities will complete a postoperative survey reporting pain scores and opioid use within 72 hours, with secondary data on OTC pain reliever use. The trial compares bupivacaine-meloxicam extended-release (Zynrelef) against traditional periarticular injections to see if Zynrelef offers better pain control or reduces opioid needs. Eligibility includes adults 18–89 with knee OA undergoing unilateral RATKA, excluding those with certain comorbidities or high BMI, among other criteria. The lead sponsor is Allegheny Singer Research Institute, with the primary site in Cranberry Township, PA.
Why it matters
Potential benefit: If successful, patients could experience less pain and lower opioid requirements after RATKA.
How similar studies have gone: Prior randomized trials in traditional TKA showed Zynrelef can match standard injections for pain and opioid use; applicability to RATKA is being explored here.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Males or females aged 18-89 years Diagnosed with knee osteoarthritis requiring surgical intervention Indicated for unilateral RATKA Exclusion Criteria: Pediatric, pregnant, or incarcerated patients BMI of more than 45 kg/m2 Prolonged opioid use history of \>5 mg/day for \>1 month History of contralateral TKA \<2 years prior to the index TKA Type 1 Hypersensitivity to NSAIDs or local anesthetics Diagnosis of severe renal disease
Where it's running
-
AHN Orthopedic Surgery Cranberry Township
Cranberry Township, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Andrew Waligora, MD — Allegheny Health Network
- Study coordinator: Obinna Ajah, MD
- Email: obinna.ajah@ahn.org
- Phone: 877-660-6777
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.