Condition

Knee Osteoarthritis (Knee OA) clinical trials and research

• 16Clinical trials
• 12Countries

Newest Knee Osteoarthritis (Knee OA) clinical trials

All recruiting trials (16)

• Platelet-rich plasma added to hyaluronic acid for knee osteoarthritis

  This study tests whether a single injection of hyaluronic acid plus autologous platelet-rich plasma helps reduce knee OA symptoms more than hyaluronic acid alone in adults with moderate knee OA.

  Recruiting Implai Sp z o.o · Warsaw, Masovian Voivodeship · NCT07785401

• Hyaluronic Acid Plus PRP Injection for Knee Osteoarthritis

  This study tests whether a single HA injection combined with a patient’s own PRP is better at easing knee OA pain than HA alone.

  Recruiting Implai Sp z o.o · Chełm, Lublin Voivodeship · NCT07784907

• Personalized pain relief for knee OA using central nervous system-based duloxetine

  This study tests whether duloxetine can improve walking and daily activity in people with knee osteoarthritis by comparing it to a placebo.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07759336

• Pressure Biofeedback vs Bolster Foam Feedback for Knee Osteoarthritis

  We’re testing whether pressure biofeedback training helps people with knee osteoarthritis improve pain, function, and muscle activation more than bolster foam feedback over eight weeks.

  Recruiting Lahore University of Biological and Applied Sciences · Lahore · NCT07731737

• Core stabilization plus knee exercises for women with knee osteoarthritis

  This project will test whether adding six weeks of core stabilization exercises to routine knee physiotherapy helps women aged 40–65 with moderate knee osteoarthritis have less pain and better function.

  Recruiting Cumhuriyet University · Sivas · NCT07482332

• Brain scans to find links between brain activity and knee replacement outcomes

  This study uses brain MRI before and after knee replacement to see if patterns of brain activity can predict which patients will be satisfied with their surgery.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT07464080

• Self-administered acupressure for knee osteoarthritis in older adults at Hong Kong community centers

  This project tests whether a self-taught acupressure program can reduce knee pain and improve function for older adults with knee osteoarthritis who attend Hong Kong community centers.

  Recruiting The Hong Kong Polytechnic University · Kowloon · NCT07329023

• Vietnamese Pain Self-Efficacy Questionnaire for people with knee osteoarthritis.

  This project tests whether the Vietnamese Pain Self-Efficacy Questionnaire gives reliable and meaningful results for people aged 50 and older with knee osteoarthritis.

  Recruiting Gia Dinh People Hospital · Ho Chi Minh City, Ho Chi Minh · NCT07130630

• Embolization treatment for knee osteoarthritis

  This study is testing a new treatment called embolization therapy to see if it can help people with knee osteoarthritis feel less pain and move better.

  Recruiting at 3 sites Next Biomedical Co., Ltd. · Ghent and 2 other locations · NCT06930677

• Comparing retro-walking and forward-walking on an underwater treadmill for knee osteoarthritis

  This study is testing whether walking backwards or forwards on an underwater treadmill helps people with knee osteoarthritis feel less pain and move better.

  Recruiting Cairo University · Cairo, Cairo Governorate and 1 other locations · NCT06896032

• Effects of Feldenkrais Exercises on Knee Osteoarthritis

  This study is testing if Feldenkrais exercises can help people with knee osteoarthritis feel less pain and move better compared to regular physical therapy.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06875817

• Comparing genicular artery embolization with steroid knee injections for osteoarthritis pain

  This trial will test whether genicular artery embolization (using Nexsphere-F) reduces knee osteoarthritis pain more than a standard corticosteroid knee injection.

  Recruiting North American Science Associates Ltd. · Charlottesville, Virginia · NCT06872567

• Reducing knee pain with Genicular Artery Embolization

  This study is testing if a new procedure called Genicular Artery Embolization can help people with knee osteoarthritis pain who haven't found relief from other treatments.

  Recruiting Phase 2 University of Utah · Salt Lake City, Utah · NCT06859164

• Vutiglabridin for knee osteoarthritis

  We will test whether a once-daily oral pill called vutiglabridin reduces pain and improves function in adults 40–75 with moderate knee osteoarthritis.

  Recruiting Phase 2 Glaceum · Seongnam-si, Gyeonggi-do · NCT06845553

• Registry for Genicular Artery Embolization in Knee Osteoarthritis

  This study is trying to see if a new procedure called genicular artery embolization can help reduce knee pain in adults with osteoarthritis who aren't able to have surgery.

  Recruiting University of Chicago · Chicago, Illinois · NCT06781463

• Understanding muscle power and control to prevent falls in knee osteoarthritis patients

  This study is trying to see if measuring muscle power and control can better predict fall risks in older adults with knee osteoarthritis than just looking at muscle strength alone.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT06611618

Related topics

Quick answers

How many Knee Osteoarthritis (Knee OA) clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (4 trials), Pakistan (2 trials), Poland (2 trials), Vietnam (1 trial), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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