Condition

Total Knee Anthroplasty clinical trials and research

• 10Clinical trials
• 7Countries

Newest Total Knee Anthroplasty clinical trials

All recruiting trials (10)

• Choose to Move Replacement Ready for OA patients waiting for hip or knee replacement

  This program tests a tailored, online version of a 3-month activity and social-connection plan for older adults with hip or knee osteoarthritis who are waiting for joint replacement surgery to see if it improves physical activity and health while they wait.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07696650

• AI-guided mobilization education for total knee replacement patients

  This study tests whether an AI-powered mobilization education video helps people recovering from total knee replacement feel less fear about moving and are better prepared to go home.

  Recruiting Kocaeli University · Kocaeli, İzmit · NCT07694895

• Ermi Knee Flexionater to help avoid motion-restoring surgery after knee replacement

  This will test whether adding the Ermi Knee Flexionater to standard physical therapy helps people 40 and older who can't bend their knee enough after a total knee replacement.

  Recruiting Ermi LLC · Houston, Texas · NCT07454356

• Cryocompression versus icepacks after total knee replacement

  This trial will test whether using a cryocompression device (Game Ready) after primary total knee replacement reduces pain, swelling, and opioid use in adult patients.

  Recruiting Clinique des Cèdres · Échirolles · NCT07366736

• Mir Shakeel teleintegrated therapy for recovery after total knee replacement

  This trial will test whether a structured telerehabilitation program (MSTITP) helps people aged 50–65 recover better after primary total knee replacement compared with standard in-person physiotherapy.

  Recruiting Lincoln University College · Lahore, Punjab Province · NCT07239258

• Acupuncture for pain after total knee replacement

  This project will try acupuncture to reduce short-term pain, opioid use, and inflammation after elective total knee replacement in adults.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT07123805

• Low-dose epinephrine with tranexamic acid during knee replacement

  This will test whether giving low-dose epinephrine together with tranexamic acid to people having knee replacement reduces blood loss, clotting complications, and hospital stay.

  Recruiting Phase 4 King Abdullah International Medical Research Center · Riyadh, Riyadh Region · NCT07089251

• Sacral ESP plus adductor canal block versus iPACK plus adductor canal block for pain control after knee replacement

  This will test whether adding a sacral erector spinae plane (ESP) block to an adductor canal block gives adults having a unilateral knee replacement as good or better pain relief and recovery as adding an iPACK block.

  Recruiting San Giovanni di Dio Hospital · Crotone · NCT07017400

• Corticosteroid injection for knee surgery patients

  This study is testing if giving corticosteroid injections to the other knee can help people with both knees affected by osteoarthritis recover better after knee surgery.

  Recruiting Phase 1/2 Unity Health Toronto · Toronto, Ontario · NCT06809998

• Total Knee Replacement: post-market safety and effectiveness registry

  This registry tests how well the Freedom Total Knee system works and stays safe after it’s been released, by following a group of patients who have this knee replacement.

  Recruiting at 2 sites Maxx Orthopedics Inc · Leawood, Kansas and 1 other locations · NCT06627699

Related topics

Quick answers

How many Total Knee Anthroplasty clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in Italy (2 trials), United States (2 trials), Canada (2 trials), Saudi Arabia (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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