Percutaneous nerve stimulation for knee osteoarthritis
Official title: Percutaneous Peripheral Temporary Neurostimulation in Moderate to Severe Knee Osteoarthritis
Run by Tanta University · NCT07637682 · Data updated 2026-11-12
A device is used to send tiny electrical impulses to nerves around the knee to see if it reduces pain for adults with moderate to severe knee OA who have not had relief from other treatments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta) |
| Status | Recruiting |
| Started | June 2, 2026 |
| Main results expected | November 2026 |
| Study ends | November 2026 |
| Registry record updated | June 18, 2026 |
| Trial ID | NCT07637682 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 30–70 with moderate to severe knee OA who have not responded to at least two oral pain meds and six weeks of physical therapy, and who cannot afford intra-articular injections or radiofrequency ablation.
✕Probably not a fit
Patients who show no meaningful pain relief or functional improvement after stimulation or who have contraindications may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines peripheral nerve stimulation (PNS) delivered via a nerve stimulator to the superior lateral genicular and saphenous nerves in adults with moderate to severe knee osteoarthritis. It targets chronic knee pain by potentially interrupting pain signals without drugs. Participants must have tried standard therapies and meet specific eligibility criteria, including age range and treatment history. The approach is invasive but minimally so, and outcomes focus on pain relief and function.
Why it matters
Potential benefit: If successful, patients may experience meaningful pain relief and improved knee function without relying on medications.
How similar studies have gone: Other reports have shown pain reduction with targeted peripheral nerve stimulation in joint pain, though experiences vary and this area remains investigational.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. adults between the ages of 30 and 70 years with a clinical diagnosis of moderate to severe knee OA who suffered knee pain. 2. Patients who cannot afford intra-articular injections or radiofrequency ablation (RFA). 3. patients who had failed 2 different oral pain medications and 6 weeks of physical therapy. Exclusion Criteria: 1. Patients with OA show improvement in pain after physiotherapy. 2. patients evaluated by an orthopaedic surgeon and deemed to be surgical candidates due to knee pathologies other than OA. 3. pregnant patients. 4. patients on anticoagulation therapy, who were not permitted to stop anticoagulation. 5. patients with previous trauma, neurological or endocrine diseases like diabetes mellitus, and knee tumors; and patients with inflammatory arthritis. 6. people who had received an intra-articular knee injection within the last 6 months. 7. Patients with tendon tears, bursitis, or calcified tendonitis as proven by imaging.
Where it's running
-
Faculty of medicine, Tanta University
Tanta, Egypt Recruiting
Study contacts
- Study coordinator: Aliaa Mamdouh Abdelaziz Farag, MD
- Email: aliaa.mamdouh@med.tanta.edu.eg
- Phone: +201069468486
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.