Long-acting local pain medicine after knee replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing first-time knee replacement are randomized to receive one of three pain-control approaches during surgery: a standard knee injection, an adductor canal nerve block, or a periarticular injection containing bupivacaine and meloxicam. The goal is to see if the long-acting Zynrelef formulation provides sustained pain relief with fewer opioid needs compared with the other methods. The trial is conducted in a real-world setting within the Henry Ford Health System, with same-day discharge as a likelihood. Outcomes focus on pain control in the immediate postoperative period and opioid consumption, among other safety measures. This Phase 4 study aims to determine whether this new treatment can improve recovery after knee arthroplasty compared with current practices.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients age 18 and older undergoing primary total knee replacement by fellowship trained Orthopedic Surgeons in Henry Ford Health System with planned outpatient same-day discharge.

Exclusion Criteria:

* Incomplete data in medical records
* Non-English speakers
* Chronic opioid use in the last 3 months
* Ipsilateral joint surgery in the last year
* Undergoing bilateral knee arthroplasty
* Cannot tolerate oral medications
* Swallowing difficulties
* Intolerance to acetaminophen, anti-inflammatories, muscle relaxants, gabapentinoids, or opioids/tramadol
* History of alcohol abuse
* Drug abuse
* Renal impairment
* Peptic ulcer disease
* GI bleeding
* Illicit narcotic usage in the past 6 months
* Chronic liver disease
* Chronic pain syndromes

Where it's running

• Henry Ford Medical Center - Grosse Pointe Cottage
  Grosse Pointe Farms, Michigan, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.