Investigating factors influencing childhood obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The RESONATE project aims to understand why some children develop obesity by analyzing data on eating behaviors, genetic and environmental influences, and brain structure and function. This observational study focuses on a sub-sample of families from the larger RESONANCE study, tracking children from infancy through middle childhood. By examining the neurodevelopmental mechanisms that affect appetite and weight gain, the study seeks to identify risk and protective factors that contribute to obesity. The findings will help lay the groundwork for early interventions to prevent or treat obesity in children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants from the RESONANCE cohort are eligible if the participant will reach 7-12 years of age during the proposed project period and have no food allergies.

Exclusion Criteria:

* Exclusion criteria for RESONANCE include:

  1. In utero exposure to alcohol, cigarette, or illicit substances;
  2. First trimester fetal US abnormalities;
  3. Complicated pregnancy (e.g., pre-eclampsia);
  4. Complicated delivery, including APGAR scores less than 8 and/or neonatal intensive care unit (NICU) admission;
  5. History of neurological (e.g., epilepsy), psychiatric (e.g., anxiety or depression requiring treatment with medication) or developmental disorder (e.g., autism spectrum disorder (ASD), dyslexia);
  6. Contraindications for MRI including metal in the body, claustrophobia.

Where it's running

• Rhode Island Hospital
  Providence, Rhode Island, United States Recruiting
• Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
  Baltimore, Maryland, United States Active not recruiting
• Johns Hopkins University School of Medicine
  Baltimore, Maryland, United States Active not recruiting
• University of Washington
  Seattle, Washington, United States Active not recruiting

Study contacts

• Principal investigator: Susan Carnell, PhD — Johns Hopkins University
• Study coordinator: Susan Carnell, PhD
• Email: susan.carnell@jhmi.edu
• Phone: 410-955-7192

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.