Daily broccoli microgreens for breast cancer survivors with obesity
Metabotyping of a Functional Food, Broccoli Microgreen, in Obese Breast Cancer Survivors
NA · University of Maryland, Baltimore · NCT07032545
This two-week test will see if eating one cup of fresh broccoli microgreens each day is doable and changes metabolism and gut health in obese breast cancer survivors.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Sex | Female |
| Sponsor | University of Maryland, Baltimore (other) |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT07032545 on ClinicalTrials.gov |
What this trial studies
This is a single-arm, two-week pilot intervention enrolling 24 obese (BMI >30) women who are 2–60 months post-curative treatment for stage I–III breast cancer at the University of Maryland, Baltimore. Participants will consume one serving (~57 g, one cup) of fresh broccoli microgreens daily and avoid other cruciferous vegetables during the intervention. Blood and fecal samples plus questionnaires will be collected at baseline and after two weeks to measure compliance, body composition, glucose and lipid markers, inflammatory markers, and gut microbiome/metabolite changes. The primary aim is to test feasibility and adherence, with secondary exploratory endpoints examining short-term metabolic and gut-health responses to the intervention.
Who should consider this trial
Good fit: Women with stage I–III breast cancer who are 2–60 months after curative treatment and have a BMI over 30 kg/m², who can avoid other cruciferous vegetables and consent to sample collection, are ideal candidates.
Not a fit: People with gastrointestinal contraindications, allergy or intolerance to cruciferous vegetables, pregnancy or breastfeeding, recent eating-disorder history, or those already taking broccoli supplements are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If successful, adding broccoli microgreens to the diet could modestly improve metabolic markers and gut health and potentially reduce obesity-related risks for cancer recurrence.
How similar studies have performed: Animal studies have shown beneficial effects of broccoli microgreens on gut health and metabolism, but human data are limited and this is an early proof-of-concept in people.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female * Had a diagnosis of breast cancer (Stage I-III) * 2 to 60 months post-curative treatment (surgery, chemotherapy, and/or radiation) * BMI \> 30 kg/m² (obese classification) * Willing to avoid cruciferous vegetables during the study * Able to sign an IRB-approved consent form Exclusion Criteria: * Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., GI conditions, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder). * Allergy or intolerance to cruciferous vegetables * Currently taking broccoli extract supplements
Where this trial is running
Baltimore, Maryland
- Breast Evaluation and Treatment Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center — Baltimore, Maryland, United States (RECRUITING)
Study contacts
- Principal investigator: Yuanyuan (Rose) Li, M.D., Ph.D. — University of Maryland
- Study coordinator: Yuanyuan (Rose) Li, M.D., Ph.D.
- Email: roseli15@umd.edu
- Phone: 13014050776
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obesity and Overweight, Breast Cancer Survivorship, breast cancer, broccoli microgreen, obesity, survivorship, gut microbiome, metabolomics