Investigating glucose utilization in obesity
Official title: Total-body Glucose Utilization in Obesity
Run by Turku University Hospital · NCT06739473 · Data updated 2026-11-12
This study is testing how emotions and cold temperatures affect blood flow and insulin's role in helping people with obesity use glucose better.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 60 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Turku University Hospital Government |
| Drugs / interventions | radiation |
| Locations | 1 site (Turku) |
| Status | Recruiting |
| Started | January 25, 2023 |
| Main results expected | December 2024 |
| Study ends | December 2024 |
| Registry record updated | December 18, 2024 |
| Trial ID | NCT06739473 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 20-60 with a BMI of either 18.5-25 kg/m2 or above 30 kg/m2.
✕Probably not a fit
Patients with a history of obesity or type 2 diabetes in the lean group, or those currently using GLP-1-agonists or insulin in the obesity group, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore how emotions and cold exposure influence blood flow in the body, as well as how insulin affects blood flow and glucose uptake in individuals with obesity. It consists of two parts: a dose escalation study to determine the lowest effective dose of a PET radiotracer, and a series of PET studies examining the effects of emotional stimuli and insulin on circulation. Participants will undergo screening, physical examinations, and glucose tolerance tests before being involved in PET imaging sessions using a Siemens Biovision Quadra PET/CT scanner.
Why it matters
Potential benefit: If successful, this study could enhance understanding of glucose metabolism in obesity, potentially leading to improved treatment strategies.
How similar studies have gone: While the specific combination of approaches in this study may be novel, similar studies have shown success in understanding metabolic processes in obesity.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 20-60 years 2. BMI either 18.5-25 kg/m2 or above 30 kg/m2 3. Use of hormonal contraception for women in child bearing age Exclusion Criteria: 1. In the lean group history of obesity or type 2 diabetes 2. In the group with obesity: current or previous use of GLP-1-agonists or insulin 3. History of eating disorders 4. Smoking, use of narcotics, excessive use of alcohol 5. Previous participation in PET studies 6. Previous significant exposure to radiation 7. Claustrophobia 8. Active plans for concieving (both sexes) 9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
Where it's running
-
Turku PET Centre
Turku, Finland Recruiting
Study contacts
- Principal investigator: Lauri Nummenmaa, Professor — University of Turku
- Study coordinator: Aino Latva-Rasku, MD, PhD
- Email: aehyyp@utu.fi
- Phone: 358+23139857
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.