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Clinical trial Recruiting at 1 site Observational Ages 10 to 80

Assessing genetic testing's role in arrhythmic myocarditis

Official title: GEAM: Yield of GEnetic Testing in Arrhythmic Myocarditis

Run by Scientific Institute San Raffaele · NCT06889662 · Data updated 2026-11-12

This study is testing how genetic testing can help people with myocarditis and heart rhythm problems by finding specific gene changes that might affect their condition.

Quick facts

Study typeObservational
Ages10 Years to 80 Years
SexAll
Enrollment262 (estimated)
SponsorScientific Institute San Raffaele
Academic / other
Locations1 site (Milan, Italy/Milan)
StatusRecruiting
StartedFebruary 25, 2025
Main results expectedSeptember 1, 2027
Study endsDecember 1, 2027
Registry record updatedMarch 21, 2025
Trial IDNCT06889662 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients aged 10 years and older diagnosed with myocarditis and experiencing ventricular arrhythmias.

Probably not a fit

Patients with obstructive coronary artery disease or those who cannot provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the role of genetic testing in patients diagnosed with myocarditis and ventricular arrhythmias. It seeks to improve diagnostic processes by identifying patients with cardiomyopathic gene variants (CGVs) and to develop risk prediction models for arrhythmic events. The study will also investigate genotype-phenotype associations to uncover disease-specific signatures that could enhance understanding of arrhythmic myocarditis. By utilizing advanced diagnostic techniques, the study hopes to clarify the implications of genetic factors in this condition.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic accuracy and risk stratification for patients with arrhythmic myocarditis.

How similar studies have gone: While the role of genetic testing in myocarditis is still being explored, previous studies have indicated potential benefits in understanding genetic contributions to arrhythmias.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

Patients with ventricular arrhythmias (VA+) and without (VA-)

* Diagnosis of myocarditis proven by EMB (ESC criteria) and/or CMR (updated Lake Louise criteria)
* Age ≥ 10 years
* Baseline ECG telemonitoring
* Written informed consent Healthy controls
* Provided a negative known history of myocarditis
* The sample must have been biobanked as part of the study IMMUNORADAR

Exclusion Criteria:

Patients with ventricular arrhythmias (VA+) and without (VA-)

* Obstructive coronary artery disease, or lack of coronary angiography/computed tomography (CT) scan in patients \>40 years.
* Absent informed consent.

Where it's running

  • Scientific Institute San Raffaele
    Milan, Italy/Milan, Italy     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Myocarditis 56Ventricular Arrythmia 17Scientific Institute San Raffaele 11
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.