Mapping the cellular responses in acute viral myocarditis
Official title: A spatially resolved molecular atlas of acute viral myocarditis at single-cell resolution
Funded at Cornell University · NIH-11041064 · Data updated 2026-11-12
This study is looking at how the heart reacts to viral infections in babies and young kids, aiming to find out which cells are involved in the inflammation and how they work, so we can better understand and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $753,450 |
| NIH project number | 5R01AI176681-03 |
| Project ID | NIH-11041064 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants and children under 11 years old who are experiencing symptoms of acute viral myocarditis.
✕Less likely to help
Patients with chronic heart conditions unrelated to viral infections may not benefit from this research.
What this research studies
This research investigates how the heart responds to viral infections, particularly focusing on acute viral myocarditis in infants and young children. By utilizing advanced techniques like spatially resolved transcriptomics and single-cell RNA sequencing, the study aims to identify the specific cells involved in the inflammatory response and their molecular characteristics. This approach will help uncover the underlying mechanisms of the disease, which are often difficult to diagnose using traditional methods. The research will also involve mouse models to better understand the disease process and its implications for treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for children suffering from viral myocarditis.
How similar studies have gone: While there has been some research on myocarditis, this approach using single-cell resolution techniques is relatively novel and has not been extensively tested in this context.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Parker, John S — Cornell University
- Study coordinator: Parker, John S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.