Understanding heart inflammation caused by cancer immunotherapy
Pathogenesis of Immune checkpoint inhibitors-induced myocarditis
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11050243
This study is looking at how certain cancer treatments can sometimes cause heart inflammation, and it's using mice to help understand why this happens so that doctors can find better ways to protect patients' hearts while they receive these therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11050243 on ClinicalTrials.gov |
What this research studies
This research investigates how immune checkpoint inhibitors, which are used to treat cancer, can lead to inflammation of the heart, known as myocarditis. The study uses a mouse model that mimics human responses to these therapies, allowing researchers to observe the effects of these drugs on heart health. By examining the immune response and the specific T cells involved, the research aims to uncover the mechanisms behind this serious side effect. The ultimate goal is to develop targeted therapies that can prevent or treat myocarditis in patients receiving immunotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients over the age of 65 who are receiving immune checkpoint inhibitors.
Not a fit: Patients who are not receiving immune checkpoint inhibitors or are under the age of 65 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved safety and treatment options for cancer patients undergoing immunotherapy.
How similar studies have performed: Previous research has shown that understanding immune-related adverse events can lead to better management strategies, indicating potential success for this approach.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CIHAKOVA, DANIELA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CIHAKOVA, DANIELA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.