Optical brain monitoring to detect large vessel blockage in stroke patients

Who could benefit from this research

What this research studies

This grant develops an inexpensive, portable optical device that measures cerebral blood flow to help detect large vessel occlusion in acute stroke patients before hospital arrival. The approach uses fast, high-quality signal data and a neural network to interpret waveform patterns, aiming to improve prehospital triage. By enabling EMS and emergency departments to identify LVO more accurately, this work could shorten time to definitive therapy and improve outcomes for stroke patients.

Why it matters

Where this research is happening

• University of Pennsylvania
  Philadelphia, United States Active

Researchers

• Principal investigator: Favilla, Christopher G. — University of Pennsylvania
• Study coordinator: Favilla, Christopher G.

Related research

Other NIH-funded projects on the same topics.

• Improving blood flow in stroke patients with large vessel occlusion

  This study is looking at a new way to help people who have had a serious type of stroke by using a special treatment called Lamiflo™ that improves blood flow, and it's for patients who might be eligible based on their imaging results.

  NIH research Shearit, LLC · Albuquerque, United States · NIH-10820012

• Sevoflurane vs. Propofol for anesthesia in stroke patients undergoing clot-removal

  This study tests whether sevoflurane or propofol used for anesthesia during endovascular treatment of an acute ischemic stroke affects the final brain damage and recovery.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT07902791

• Tenecteplase or Reteplase Bridging Before Thrombectomy in Acute Ischemic Stroke

  This trial tests whether giving tenecteplase or reteplase before mechanical thrombectomy helps people with acute ischemic stroke due to large vessel occlusion, compared with doing thrombectomy alone.

  Recruiting Phase 3 Beijing Tiantan Hospital · Beijing, Beijing Municipality and 4 other locations · NCT07748039

• Intra-arterial Alteplase after successful reperfusion following mechanical thrombectomy

  This trial tests whether giving a small amount of alteplase directly into the artery after a successful thrombectomy helps adults with acute ischemic stroke recover better.

  Recruiting at 9 sites Phase 3 115 People's Hospital · An Giang and 12 other locations · NCT07727395

• Sivelestat added to endovascular clot retrieval for acute anterior circulation stroke

  This study tests whether giving sivelestat sodium alongside mechanical thrombectomy helps improve outcomes for adults with acute ischemic stroke due to large vessel occlusion.

  Recruiting at 2 sites Xuanwu Hospital, Beijing · Weifang, Shandong and 1 other locations · NCT07552610

• Injecting methylprednisolone into the artery right after clot removal for large-vessel stroke

  This trial will test whether giving methylprednisolone into the artery immediately after successful clot removal, followed by three days of IV methylprednisolone, helps adults with anterior large-vessel occlusion strokes recover better.

  Recruiting Phase 2 Tang-Du Hospital · Xi'an, Shaanxi · NCT07516522

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.