Comparing genicular artery embolization with steroid knee injections for osteoarthritis pain
Resorbable Embolization MicroSpheres for OsteoaRthritis Benefit
This trial will test whether genicular artery embolization (using Nexsphere-F) reduces knee osteoarthritis pain more than a standard corticosteroid knee injection.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 126 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | North American Science Associates Ltd. Research network |
| Locations | 1 site (Charlottesville, Virginia) |
| Trial ID | NCT06872567 on ClinicalTrials.gov |
What this trial studies
This is a prospective, randomized, controlled trial comparing genicular artery embolization (GAE) using Nexsphere-F to intra-articular corticosteroid injection for people with localized knee osteoarthritis pain. Eligible participants must be suitable candidates for an arterial vascular access procedure and willing to follow study visits. Participants are randomized to receive either GAE or a steroid injection, with clinical follow-up to monitor pain, function, and safety outcomes over time. The lead site is the University of Virginia and the study is sponsored by North American Science Associates Ltd. with Next Biomedical Co., Ltd. as a collaborator.
Who should consider this trial
Good fit: People with localized knee osteoarthritis pain who are appropriate candidates for an arterial vascular access procedure and willing to comply with study visits are ideal candidates.
Not a fit: Patients who are allergic to implant materials, unable to undergo arterial access, or unwilling/unable to follow study requirements are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, GAE could offer longer-lasting pain relief for knee osteoarthritis and reduce the need for repeat steroid injections or surgery.
How similar studies have performed: Small early studies and case series have reported promising pain relief with genicular artery embolization, but larger randomized data remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient has localized knee pain * Must be an appropriate candidate for arterial vascular access procedure Exclusion Criteria: * Known sensitivity or allergy to implant materials * Unable or unwilling to comply with study requirements
Where this trial is running
Charlottesville, Virginia
- University of Virginia — Charlottesville, Virginia, United States (Recruiting)
Study contacts
- Study coordinator: Ziv J Haskal, MD
- Email: haskalembo@gmail.com
- Phone: 16463691570
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.