Condition

Chronic Knee Pain clinical trials and research

• 11Clinical trials
• 1NIH research projects
• 7Countries

Newest Chronic Knee Pain clinical trials

All recruiting trials (11)

• Personalized pain relief for knee OA using central nervous system-based duloxetine

  This study tests whether duloxetine can improve walking and daily activity in people with knee osteoarthritis by comparing it to a placebo.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07759336

• STAR & BMI: Can thigh muscle and fat measurements predict knee pain relief after a nerve block

  This study tests whether ultrasound measurements of thigh muscle and subcutaneous fat can help predict who will have pain relief after a genicular nerve block for knee osteoarthritis.

  Recruiting Gaziosmanpasa Research and Education Hospital · Istanbul · NCT07712419

• Nerve branches to the vastus medialis added to genicular nerve treatment for chronic knee pain

  This observational study tests whether adding pulsed radiofrequency to the nerve branches near the vastus medialis to standard genicular nerve treatment helps people with chronic knee osteoarthritis pain.

  Recruiting Diskapi Teaching and Research Hospital · Ankara · NCT07703293

• Why walking causes different amounts of knee pain in people with osteoarthritis

  This project will see if differences in the brain, joint imaging, movement, and sensory responses explain why adults 45–80 with knee osteoarthritis have different levels of walking pain.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07308873

• Central pain sensitivity and its effect on nerve control of muscles in people with chronic knee pain or fibromyalgia

  This project tests whether increased central pain sensitivity is linked to changes in the nerve signals that control muscles in adults 40+ with chronic knee pain or fibromyalgia compared with pain-free volunteers.

  Recruiting University of Nottingham · Derby, Derbyshire · NCT07281651

• Auricular point acupressure self-management for chronic musculoskeletal pain in rural communities

  This program will test whether a 4-week auricular point acupressure self-management approach (delivered via a smartphone app with remote training or with in-person training) helps adults in rural areas reduce chronic musculoskeletal pain and improve activity.

  Recruiting The University of Texas Health Science Center, Houston · Columbia, South Carolina and 2 other locations · NCT07179016

• Focused ultrasound nerve treatment for medial knee osteoarthritis pain

  This study will try focused ultrasound delivered through the skin to disrupt a small medial knee nerve and reduce chronic osteoarthritis pain in adults with moderate-to-severe medial knee pain.

  Recruiting FUSMobile Inc. · North York, Ontario · NCT07178951

• Effects of Theta Burst Stimulation on Pain and Cognition in Older Adults

  This study is testing whether a new brain stimulation technique can help older adults with chronic pain feel better and think more clearly.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT06709963

• Comparing nerve stimulation and steroid injections for chronic knee pain

  This study is testing whether nerve stimulation therapy works better than steroid injections for improving knee movement in people with chronic knee pain.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06004882

• Radiofrequency ablation for chronic pain after knee surgery

  This study tests whether a treatment called radiofrequency ablation can help people with ongoing knee pain after knee surgery feel better.

  Recruiting Consorci Sanitari de l'Alt Penedès i Garraf · Barcelona, Catalonia · NCT05920382

• Using light therapy to relieve chronic knee pain in obese patients preparing for weight loss surgery

  This study is testing whether light therapy can help reduce knee pain and improve movement in obese patients getting ready for weight loss surgery.

  Recruiting Phase 2/3 University of Nove de Julho · Goiânia, Goiás · NCT05816798

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• COSMIIC tSNIP: a painless, targeted nerve block for chronic knee pain

  A new, localized light-based treatment aims to temporarily quiet pain signals from the knee to help people with chronic knee pain feel better.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11346539

Related topics

Quick answers

How many Chronic Knee Pain clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (4 trials), Turkey (Türkiye) (2 trials), Canada (1 trial), Spain (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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