Brain scans to find links between brain activity and knee replacement outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses functional MRI to map brain network activity before and after primary total knee arthroplasty (TKA). Researchers will compare pre- and postoperative brain connectivity and link those changes to patient-reported pain, function, and satisfaction. The aim is to identify brain-based markers that could predict who will remain satisfied or dissatisfied after surgery. The work is performed at The Ottawa Hospital and excludes people with major neurological disorders, cognitive impairment, revision or bilateral TKA, or chronic opioid use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male and female patients aged 18 years or older
2. Primary TKA
3. Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis

Exclusion Criteria:

1. Inability or refusal to sign informed consent form
2. Non-English or French speaking, and no licensed translator, family member or substitute decision maker available
3. History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis
4. Cognitive impairment or dementia
5. Revision and/or Bilateral TKA
6. Chronic Opioid use

Where it's running

• The Ottawa Hospital
  Ottawa, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Simon Garceau — The Ottawa Hospital
• Study coordinator: Sanjula Costa
• Email: scosta@ohri.ca
• Phone: 613-737-8899

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.