Condition

Knee Arthritis, Osteoarthritis clinical trials and research

• 16Clinical trials
• 2New in 30 days
• 8Countries

Newest Knee Arthritis, Osteoarthritis clinical trials

All recruiting trials (16)

• Single-center, first-in-human injection of ceAF for knee osteoarthritis

  This early-stage study tests a single knee injection of ceAF to see if it is safe and helps reduce pain and improve function in adults with knee osteoarthritis.

  Recruiting Phase 1 Anhui HygeianCells BioMedical Co., Ltd. · Huangshan City, Anhui · NCT07902128

• Radial Shock Wave Therapy for knee bone marrow edema in people with knee OA

  A noninvasive shock wave therapy is tested to see if it helps people aged 40–70 with knee osteoarthritis and bone marrow edema.

  Recruiting Dokuz Eylul University · Izmir, Balcova · NCT07887893

• Motivational Interviewing Plus Exercise for knee osteoarthritis

  This study tests whether adding motivational interviewing to a neuromuscular and home exercise program helps people with knee osteoarthritis improve pain control and get more active.

  Recruiting Kutahya Health Sciences University · Afyonkarahisar, Türkiye · NCT07767812

• How patient education helps people with chronic musculoskeletal pain stick to home exercise for pain relief

  A structured patient education program is tested to see if it helps people with chronic low back pain, knee osteoarthritis, and shoulder problems stick with their home exercise plan to relieve pain.

  Recruiting Imam Abdulrahman Bin Faisal University · Dammam, Eastern Province · NCT07764354

• Eccentric gastrocnemius strengthening vs low-load blood flow restriction training for knee osteoarthritis

  This study tests whether eccentric strengthening of the calf muscle or low-load blood flow restriction training can improve strength and function in people with knee osteoarthritis.

  Recruiting Riphah International University · Rawalpindi, Punjab Province · NCT07733518

• Pressure Biofeedback vs Bolster Foam Feedback for Knee Osteoarthritis

  We’re testing whether pressure biofeedback training helps people with knee osteoarthritis improve pain, function, and muscle activation more than bolster foam feedback over eight weeks.

  Recruiting Lahore University of Biological and Applied Sciences · Lahore · NCT07731737

• Daily knee sleeve use in older adults with chronic knee pain

  This trial tests whether wearing a knee sleeve every day can slow knee OA progression and reduce knee pain and disability over five years in adults aged 50–64 with chronic knee pain.

  Recruiting Knee Sleeve Trial Collaborative, LLC · Springfield, Massachusetts · NCT07674901

• Perturbation-based balance training vs progressive neuromuscular training alongside standard physiotherapy for knee osteoarthritis

  This trial tests whether perturbation-based balance training adds benefit over progressive neuromuscular training when used with usual physiotherapy for people with knee osteoarthritis and chronic knee pain.

  Recruiting Ibadat International University, Islamabad · Islamabad, ICT · NCT07653841

• Perturbation-based balance training vs progressive neuromuscular training alongside standard physiotherapy for knee osteoarthritis

  This trial tests whether perturbation-based balance training adds benefit over progressive neuromuscular training when used with usual physiotherapy for people with knee osteoarthritis and chronic knee pain.

  Recruiting Ibadat International University, Islamabad · Islamabad, ICT · NCT07653841

• How Lipedema Affects Knee Osteoarthritis

  This study compares people with knee osteoarthritis who have lipedema to those with osteoarthritis but without lipedema to see if lipedema changes knee pain and structure.

  Recruiting Izmir Democracy University · Izmir, İzmir and 1 other locations · NCT07575555

• Mobilized balance platform exercises for people with knee osteoarthritis

  This will test whether adding Huber 360 balance platform exercises to standard physical therapy helps people aged 45–65 with moderate knee osteoarthritis improve balance, reduce pain, and function better in daily life.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara · NCT07575425

• High-intensity laser versus standard physical therapy for knee osteoarthritis

  This trial will try high-intensity laser therapy plus exercises against standard physical therapy plus exercises in adults aged 40–75 with mild-to-moderate knee osteoarthritis to see which reduces pain and improves knee function.

  Recruiting Erbil Polytechnic University · Erbil, Erbil Governorate · NCT07551245

• Comparing StromaForte (donor bone-marrow mesenchymal stromal cells) versus hyaluronic acid injections for knee osteoarthritis

  This trial will test whether injections of StromaForte (donor bone-marrow mesenchymal stromal cells) relieve pain and improve function in adults with radiographic knee osteoarthritis better than hyaluronic acid injections.

  Recruiting Phase 2/3 Cellcolabs Clinical SPV Limited · Abu Dhabi · NCT07542808

• Cryoneurolysis before total knee replacement surgery

  This trial will test whether freezing the genicular nerves at least 24 hours before total knee replacement reduces long-term pain and improves recovery for adults having primary TKA for osteoarthritis.

  Recruiting Attikon Hospital · Athens · NCT07425457

• Improving stair climbing in knee osteoarthritis with flywheel eccentric training

  This trial will test whether using a flywheel machine for eccentric overload exercise helps people aged 40–70 with moderate knee osteoarthritis climb stairs more safely and more easily.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07424352

• Low-dose epinephrine with tranexamic acid during knee replacement

  This will test whether giving low-dose epinephrine together with tranexamic acid to people having knee replacement reduces blood loss, clotting complications, and hospital stay.

  Recruiting Phase 4 King Abdullah International Medical Research Center · Riyadh, Riyadh Region · NCT07089251

Related topics

Quick answers

How many Knee Arthritis, Osteoarthritis clinical trials are recruiting right now?

16, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in Turkey (Türkiye) (4 trials), Pakistan (4 trials), United States (2 trials), Saudi Arabia (2 trials), United Arab Emirates (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1, Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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