Embolization treatment for knee osteoarthritis
Official title: A Prospective, Single-arm, Multinational, Multi-center, Clinical Study to Evaluate the Performance and Safety of Musculoskeletal Embolization Using NBGM200 in Patients With Knee Degenerative Osteoarthritis
Run by Next Biomedical Co., Ltd. · NCT06930677 · Data updated 2026-11-12
This study is testing a new treatment called embolization therapy to see if it can help people with knee osteoarthritis feel less pain and move better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 72 (estimated) |
| Sponsor | Next Biomedical Co., Ltd. Industry-sponsored |
| Locations | 3 sites (Ghent and 2 other locations) |
| Status | Recruiting |
| Started | April 17, 2025 |
| Main results expected | February 2027 |
| Study ends | February 2027 |
| Registry record updated | November 19, 2025 |
| Trial ID | NCT06930677 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with knee osteoarthritis confirmed by MR-imaging.
✕Probably not a fit
Patients with current local infections or a life expectancy of less than six months may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of embolization therapy using NBGM200 in patients diagnosed with knee osteoarthritis. The approach involves targeting the affected area to potentially alleviate pain and improve function. Patients will be selected based on MR-imaging confirmation of osteoarthritis, while those with local infections or limited life expectancy will be excluded. The study aims to evaluate the safety and efficacy of this novel treatment method.
Why it matters
Potential benefit: If successful, this treatment could provide significant pain relief and improved mobility for patients suffering from knee osteoarthritis.
How similar studies have gone: While embolization therapy is a novel approach for knee osteoarthritis, similar studies in other conditions have shown promising results, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Osteoarthritis proven by MR-imaging Exclusion Criteria: * Current local infection * Life expectancy less than 6 months
Where it's running
-
University Hospital Ghent
Ghent, Belgium Recruiting -
Uz Leuven
Leuven, Belgium Recruiting -
Elisabeth-Tweesteden Hospital
Tilburg, Netherlands Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Platelet-rich plasma added to hyaluronic acid for knee osteoarthritis
This study tests whether a single injection of hyaluronic acid plus autologous platelet-rich plasma helps reduce knee OA symptoms more than hyaluronic acid alone in adults with moderate knee OA.
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Hyaluronic Acid Plus PRP Injection for Knee Osteoarthritis
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Personalized pain relief for knee OA using central nervous system-based duloxetine
This study tests whether duloxetine can improve walking and daily activity in people with knee osteoarthritis by comparing it to a placebo.
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Pressure Biofeedback vs Bolster Foam Feedback for Knee Osteoarthritis
We’re testing whether pressure biofeedback training helps people with knee osteoarthritis improve pain, function, and muscle activation more than bolster foam feedback over eight weeks.
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Core stabilization plus knee exercises for women with knee osteoarthritis
This project will test whether adding six weeks of core stabilization exercises to routine knee physiotherapy helps women aged 40–65 with moderate knee osteoarthritis have less pain and better function.
-
Brain scans to find links between brain activity and knee replacement outcomes
This study uses brain MRI before and after knee replacement to see if patterns of brain activity can predict which patients will be satisfied with their surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.