Understanding how a specific protein modification affects intellectual disability in males
Official title: The Role of the O-GlcNAc Modification in X-linked Intellectual Disability
Funded at University of Georgia · NIH-11034104 · Data updated 2026-11-12
This study is looking at how changes in a specific protein related to X-linked intellectual disability (which affects some boys) might help us find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $370,713 |
| NIH project number | 5R01HD110099-03 |
| Project ID | NIH-11034104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are males diagnosed with X-linked intellectual disability, particularly those with identified mutations in the OGT gene.
✕Less likely to help
Patients with intellectual disabilities not linked to X-linked genetic factors or those without OGT mutations may not benefit from this research.
What this research studies
This research investigates the role of a protein modification called O-GlcNAc in X-linked intellectual disability (XLID), which affects about 1 in 500 males. The study focuses on unique mutations in the gene responsible for O-GlcNAc transferase (OGT) that lead to changes in the protein's structure and function. By using advanced techniques like Cas9-engineered stem cells and isotope-based approaches, researchers aim to understand how these mutations impact protein interactions and cellular processes. This knowledge could help identify new therapeutic targets for XLID.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or interventions for individuals with X-linked intellectual disability.
How similar studies have gone: Previous research has shown promising results in understanding the role of protein modifications in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Wells, Lance — University of Georgia
- Study coordinator: Wells, Lance
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.