Understanding mental health crises in youth with intellectual disabilities

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on youth aged 7-17 with intellectual developmental disabilities (IDDs) who present to the emergency department at Rady Children's Hospital due to a mental health crisis. The study aims to collect biological samples and analyze genomic, medical, and psychiatric profiles to identify risk factors associated with mental health crises in this population. By comparing these youth to historical cohorts, the research seeks to leverage machine learning and genomic sequencing to develop better models of psychiatric care and early identification of at-risk individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Child/adolescents admitted to the RCHSD ED with an IDD presenting in a MHC that includes, but is not limited to:

* Aggression towards others
* Severe agitation
* Self-injury
* Elopement

OR

Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. (Family members are eligible for participation in this study if they presumed genetically related to a participant).

Exclusion Criteria:

Child/Adolescents participants who do not meet any of the inclusion criteria, or those who:

* Already received any prior whole genome sequencing or exome sequencing
* Unable to approach the family or patient for enrollment
* Unable to obtain informed consent
* family members are ineligible for participation in this study if they are known to not be genetically related to the child/adolescent participant and/or if they are a member of a protected research population.

Where it's running

• Rady Children's Hospital San Diego
  San Diego, California, United States Recruiting

Study contacts

• Principal investigator: Aaron Besterman, MD, MD — Rady Children's Institute for Genomic Medicine
• Study coordinator: Aaron Besterman, MD
• Email: abesterman@health.ucsd.edu
• Phone: 858-576-1700

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.