Using driving pressure to improve lung ventilation after aortic dissection surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of driving pressure-guided lung protective ventilation in reducing postoperative hypoxemia in patients who have undergone surgical repair of acute type A aortic dissection. The study is an open-label, randomized control trial that aims to measure the incidence of hypoxemia within seven days post-surgery, defined by specific arterial oxygen levels. By utilizing driving pressure as a ventilation strategy, the trial seeks to improve oxygenation outcomes and reduce complications associated with this high-risk surgical procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Able to sign Informed Consent and Release of Medical Information Forms;
2. Age ≥ 14 years and ≤ 70 years old;
3. Being confirmed the diagnosis by chest computed tomography angiography and receiving the surgical repair of acute type A aortic dissection.

Exclusion Criteria:

1. Age \< 14 years or \> 70 years old;
2. Sepsis before surgery;
3. Chronic pulmonary disease including lung infection or asthma requiring long-term pharmacotherapy;
4. History of lung tumor;
5. Obstructive sleep apnea hypopnea syndrome requiring long-term noninvasive mechanical ventilation support;
6. Heart failure requiring catecholamines or invasive mechanical ventilation support;
7. Body mass index \> 30 Kg·m-2;
8. Being reluctance to participate this study.

Where it's running

• Fujian medical university union hospital
  Fuzhou, Fujian, China Recruiting

Study contacts

• Principal investigator: Yong Lin, MD — Fujian Medical University Union Hospital
• Study coordinator: Yong Lin, MD
• Email: birdman1983@163.com
• Phone: 13805064575

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.