Using driving pressure to improve lung ventilation after aortic dissection surgery

The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an Open-label, Randomized Control Clinical Trial

This study is testing if a special way of helping patients breathe after aortic dissection surgery can lower the chances of low oxygen levels in their blood.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 43 (estimated)
• Ages: 14 Years to 70 Years
• Sex: All
• Sponsor: Fujian Medical University Union Hospital (Academic / other)
• Locations: 1 site (Fuzhou, Fujian)
• Trial ID: NCT06361420 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness of driving pressure-guided lung protective ventilation in reducing postoperative hypoxemia in patients who have undergone surgical repair of acute type A aortic dissection. The study is an open-label, randomized control trial that aims to measure the incidence of hypoxemia within seven days post-surgery, defined by specific arterial oxygen levels. By utilizing driving pressure as a ventilation strategy, the trial seeks to improve oxygenation outcomes and reduce complications associated with this high-risk surgical procedure.

Who should consider this trial

Good fit: Ideal candidates for this study are patients aged 14 to 70 years who are undergoing surgical repair for acute type A aortic dissection.

Not a fit: Patients with chronic pulmonary diseases, significant obesity, or those requiring long-term mechanical ventilation support may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative hypoxemia and improve recovery outcomes for patients undergoing surgery for acute type A aortic dissection.

How similar studies have performed: Previous studies have shown that driving pressure is associated with improved survival in acute respiratory distress syndrome, suggesting potential success for this novel approach in a surgical context.

Eligibility criteria

Inclusion Criteria:

1. Able to sign Informed Consent and Release of Medical Information Forms;
2. Age ≥ 14 years and ≤ 70 years old;
3. Being confirmed the diagnosis by chest computed tomography angiography and receiving the surgical repair of acute type A aortic dissection.

Exclusion Criteria:

1. Age \< 14 years or \> 70 years old;
2. Sepsis before surgery;
3. Chronic pulmonary disease including lung infection or asthma requiring long-term pharmacotherapy;
4. History of lung tumor;
5. Obstructive sleep apnea hypopnea syndrome requiring long-term noninvasive mechanical ventilation support;
6. Heart failure requiring catecholamines or invasive mechanical ventilation support;
7. Body mass index \> 30 Kg·m-2;
8. Being reluctance to participate this study.

Where this trial is running

Fuzhou, Fujian

• Fujian medical university union hospital — Fuzhou, Fujian, China (Recruiting)

Study contacts

• Principal investigator: Yong Lin, MD — Fujian Medical University Union Hospital
• Study coordinator: Yong Lin, MD

Conditions Hypoxemia; Ventilator Lung; Driving Pressure; Lung Protective Ventilation; Aortic Dissection; Hypoxia; Postoperative Pulmonary Complications