Predicting occult low oxygen events in adults with acute respiratory failure
Official title: Predicting occult hypoxemia occurrence and determining future outcomes
Funded at University of Pennsylvania · NIH-11352884 · Data updated 2026-11-12
A small, patient-focused project aims to build a practical model to predict hidden low oxygen levels in adults with acute respiratory failure and understand what happens to them afterward.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $243,750 |
| NIH project number | 1R03HL185220-01 |
| Project ID | NIH-11352884 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years or older admitted with acute respiratory failure or related conditions.
✕Less likely to help
Patients without occult hypoxemia or those not captured by the predictive model may not directly benefit.
What this research studies
This project seeks to create a prospective prediction model to identify occult hypoxemia in adults hospitalized with acute respiratory failure. It will use advanced study design and causal methods to understand long-term outcomes for those who experience occult hypoxemia. The goal is to inform future trials and system-wide strategies that reduce related harms and improve patient care.
Why it matters
Potential benefit: If successful, the model could help clinicians detect dangerousoxygen shortfalls sooner and guide interventions to prevent long-term complications.
How similar studies have gone: Previous work has shown signals of occult hypoxemia, but robust long-term outcomes and effective mitigation strategies remain to be proven.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Chesley, Christopher Francis — University of Pennsylvania
- Study coordinator: Chesley, Christopher Francis
Related research
Other NIH-funded projects on the same topics.
-
Hypoxemia during Sleep in Sickle Cell Disease: How Common is It and How Might Treatments Help
This study looks at how low oxygen during sleep affects adults with sickle cell disease and how they respond to therapy across multiple urban and rural sites.
-
Novel alveolar factors driving low oxygen in liver-related lung disease
A patient-focused study will explore how high bile acids in cirrhosis may harm tiny air sacs in the lungs, causing breathing problems in hepatopulmonary syndrome.
-
Intermittent Hypoxemia in Early Life and Sleep in Preterm Children
A study following school-age children who were born extremely preterm to understand how early breathing problems in the NICU relate to their sleep and health today.
-
Postnatal low oxygen and heart immaturity impacting recovery after pediatric heart surgery
Researchers will study how low oxygen levels after birth and immature heart cells affect recovery after heart surgery in children with congenital heart disease.
-
Understanding injury in preterm infants with low oxygen levels
This study is looking at preterm babies who sometimes have low oxygen levels, and it aims to understand what causes harm to them and find new ways to help diagnose and treat these issues, all to improve their health and well-being.
-
Dry powder lung surfactant aerosol for people with low oxygen or ARDS on breathing support
This project is creating a dry powder lung surfactant you could inhale to help adults with low oxygen or ARDS who are on oxygen, noninvasive breathing support, or ventilators.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.