Comparing three social cognition tests in adults with early Huntington disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll 20 adults with early Huntington disease and 20 age- and sex-matched control participants to compare performance on three social cognition measures. Participants will complete the Double Movie for the Assessment of Social Cognition-Multiple Choice (DMASC-MC), the Reading the Mind in the Eyes Test, and the Emotion Hexagon Test, and will be assessed by a physician and a psychologist. Inclusion requires a clinical HD diagnosis with CAG ≥40 for the HD group and no family history or a negative pre-symptomatic gene test for controls, with exclusions for dementia (MOCA or MMSE <19), other neurological disorders, active psychosis, substance addiction, non-Swedish native language, or severe sensory deficits. The design is cross-sectional and powered for group differences between early HD and matched controls.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Inclusion criteria for persons with HD

1. Clinical diagnosis of HD
2. CAG repeat: 40 and more

Inclusion criteria for control group

1\. No heritage of HD or negative pre-symptomatic HD gene test

Exclusion Criteria:

Participants in both groups are excluded from the study if any of the following criteria apply:

1. Dementia or MOCA\<19, The Mini Mental State Examination (MMSE) \<19
2. Other neurological disorders
3. Ongoing psychosis
4. Ongoing alcohol/drug addiction
5. Other native language than Swedish
6. Severe problems with vision and hearing

Where it's running

• Skane University Hospital, Region Skane
  Lund, Sweden Recruiting

Study contacts

• Principal investigator: Asa Petersen, MD PhD — Department of Psychiatry, Skåne University Hospital
• Study coordinator: Asa Petersen, MD, PhD
• Email: asa.petersen@med.lu.se
• Phone: +46462221686

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.