Understanding how ribosome stalling affects Huntington disease
Official title: Mechanisms of Translational Dysregulation in Huntington Disease
Funded at Florida Atlantic University · NIH-11264540 · Data updated 2026-11-12
This study is looking at how a problem with protein production in the brain might contribute to Huntington disease, which could help us find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $381,250 |
| NIH project number | 7R01NS138278-02 |
| Project ID | NIH-11264540 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Huntington disease, particularly those experiencing early to moderate symptoms.
✕Less likely to help
Patients with advanced Huntington disease or those without the genetic mutation associated with the condition may not benefit from this research.
What this research studies
This research investigates the role of ribosome stalling in Huntington disease (HD), a genetic disorder that leads to neurodegeneration and various symptoms. The study focuses on the huntingtin protein, which, when mutated, disrupts normal protein synthesis in the brain. By employing advanced techniques like super-resolution ribosome profiling, the researchers aim to uncover how the mutated protein interacts with ribosomes and RNA, potentially leading to new insights into the disease's mechanisms. The findings could pave the way for developing targeted therapies to mitigate the effects of HD.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve the quality of life for individuals with Huntington disease.
How similar studies have gone: Previous research has shown promising results in understanding the molecular mechanisms of Huntington disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Florida Atlantic University
Boca Raton, United States Active
Researchers
- Principal investigator: Subramaniam, Srini — Florida Atlantic University
- Study coordinator: Subramaniam, Srini
Related research
Other NIH-funded projects on the same topics.
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Harnessing neuron-derived vesicles to find Huntington’s disease biomarkers
A research project aims to identify brain-derived biomarkers in blood that reflect Huntington disease activity, using neuronal extracellular vesicles as the signal source.
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Understanding how blood flow problems in the brain affect Huntington’s disease
A study at a major hospital is looking at how blood vessels in the brain may contribute to symptoms and brain changes in Huntington’s disease.
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Rhes‑SUMO pathway's role in Huntington's disease
This work looks at whether the Rhes‑SUMO protein system increases toxic huntingtin and helps it spread in the brain, which may explain early striatal damage in people with Huntington's disease.
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Rhes-SUMO Pathway and Huntington Disease in Mice
A study in mouse models explores how the Rhes-SUMO pathway may drive brain and nerve cell vulnerability in Huntington disease.
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Investigating the role of the Rhes-SUMO pathway in Huntington's disease
This study is looking at how a specific pathway in the brain might affect the worsening of Huntington's disease, with the hope of finding new ways to help manage the symptoms and slow down the disease for those living with it.
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Understanding how Huntington disease disrupts protein production in brain cells
Researchers are studying Huntington disease to learn how a faulty protein blocks ribosomes and slows protein-making in brain cells, which may contribute to movement and thinking problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.