Understanding how ribosome stalling affects Huntington disease
Mechanisms of Translational Dysregulation in Huntington Disease
This study is looking at how a problem with protein production in the brain might contribute to Huntington disease, which could help us find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project ID | NIH-11264540 on NIH RePORTER |
What this research studies
This research investigates the role of ribosome stalling in Huntington disease (HD), a genetic disorder that leads to neurodegeneration and various symptoms. The study focuses on the huntingtin protein, which, when mutated, disrupts normal protein synthesis in the brain. By employing advanced techniques like super-resolution ribosome profiling, the researchers aim to uncover how the mutated protein interacts with ribosomes and RNA, potentially leading to new insights into the disease's mechanisms. The findings could pave the way for developing targeted therapies to mitigate the effects of HD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington disease, particularly those experiencing early to moderate symptoms.
Not a fit: Patients with advanced Huntington disease or those without the genetic mutation associated with the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve the quality of life for individuals with Huntington disease.
How similar studies have performed: Previous research has shown promising results in understanding the molecular mechanisms of Huntington disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Boca Raton, United States
- Florida Atlantic University — Boca Raton, United States (Active)
Researchers
- Principal investigator: Subramaniam, Srini — Florida Atlantic University
- Study coordinator: Subramaniam, Srini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.