Condition
APOE-4 Positive clinical trials and research
As of November 12, 2026, Find a Trial lists 3 APOE-4 Positive clinical trials that are recruiting, in United States. By phase: Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1Country
Newest APOE-4 Positive clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Sirolimus for ApoE4 Carriers: Testing Brain Blood Flow in Women 45-65 | Phase 1 | Columbia, Missouri | Recruiting | Jul 27, 2026 |
| Predicting pre-dementia progression in APOE‑ε4 carriers | — | San Diego, California | Recruiting | Apr 7, 2026 |
| Evaluating retinal imaging for neurodegenerative diseases | — | Durham, North Carolina | Recruiting | Jul 28, 2017 |
All recruiting trials (3)
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Sirolimus for ApoE4 Carriers: Testing Brain Blood Flow in Women 45-65
Researchers will test whether sirolimus can improve brain blood flow in healthy ApoE4-positive women ages 45 to 65 compared with a placebo.
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Predicting pre-dementia progression in APOE‑ε4 carriers
This project will try a combined genetic, blood, and wearable-monitoring model to see if it can predict which cognitively normal or very mildly impaired adults aged 55+ with an APOE‑ε4 gene will develop biomarker-confirmed MCI within 24 months.
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Evaluating retinal imaging for neurodegenerative diseases
This study is testing if special eye scans can help spot early signs of neurodegenerative diseases like Alzheimer's and Parkinson's in people.
Related topics
Quick answers
How many APOE-4 Positive clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.