Investigating the role of the Rhes-SUMO pathway in Huntington's disease
Official title: Rhes-SUMO Pathway in Huntington disease
Funded at University of Florida · NIH-11175740 · Data updated 2026-11-12
This study is looking at how a specific pathway in the brain might affect the worsening of Huntington's disease, with the hope of finding new ways to help manage the symptoms and slow down the disease for those living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 21, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $27,550 |
| NIH project number | 3R01NS128225-03S1 |
| Project ID | NIH-11175740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Huntington's disease or those at risk of developing it due to genetic factors.
✕Less likely to help
Patients with other neurodegenerative diseases unrelated to Huntington's disease may not receive any benefit from this research.
What this research studies
This research focuses on understanding how the Rhes-SUMO pathway contributes to the progression of Huntington's disease (HD). It explores the interactions between the mutant huntingtin protein and the Rhes protein, which may influence neuronal vulnerability and the spread of toxic proteins in the brain. By studying these mechanisms, the research aims to uncover potential therapeutic targets that could mitigate the effects of HD. Patients may benefit from insights gained into the biological processes that lead to HD symptoms and progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent the progression of Huntington's disease.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of Huntington's disease, but the specific role of the Rhes-SUMO pathway is still being explored.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Subramaniam, Srini — University of Florida
- Study coordinator: Subramaniam, Srini
Related research
Other NIH-funded projects on the same topics.
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Harnessing neuron-derived vesicles to find Huntington’s disease biomarkers
A research project aims to identify brain-derived biomarkers in blood that reflect Huntington disease activity, using neuronal extracellular vesicles as the signal source.
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Understanding how blood flow problems in the brain affect Huntington’s disease
A study at a major hospital is looking at how blood vessels in the brain may contribute to symptoms and brain changes in Huntington’s disease.
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Rhes‑SUMO pathway's role in Huntington's disease
This work looks at whether the Rhes‑SUMO protein system increases toxic huntingtin and helps it spread in the brain, which may explain early striatal damage in people with Huntington's disease.
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Understanding how ribosome stalling affects Huntington disease
This study is looking at how a problem with protein production in the brain might contribute to Huntington disease, which could help us find new ways to treat the condition.
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Rhes-SUMO Pathway and Huntington Disease in Mice
A study in mouse models explores how the Rhes-SUMO pathway may drive brain and nerve cell vulnerability in Huntington disease.
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Understanding how Huntington disease disrupts protein production in brain cells
Researchers are studying Huntington disease to learn how a faulty protein blocks ribosomes and slows protein-making in brain cells, which may contribute to movement and thinking problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.