Investigating the role of the Rhes-SUMO pathway in Huntington's disease
Rhes-SUMO Pathway in Huntington disease
This study is looking at how a specific pathway in the brain might affect the worsening of Huntington's disease, with the hope of finding new ways to help manage the symptoms and slow down the disease for those living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11175740 on NIH RePORTER |
What this research studies
This research focuses on understanding how the Rhes-SUMO pathway contributes to the progression of Huntington's disease (HD). It explores the interactions between the mutant huntingtin protein and the Rhes protein, which may influence neuronal vulnerability and the spread of toxic proteins in the brain. By studying these mechanisms, the research aims to uncover potential therapeutic targets that could mitigate the effects of HD. Patients may benefit from insights gained into the biological processes that lead to HD symptoms and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease or those at risk of developing it due to genetic factors.
Not a fit: Patients with other neurodegenerative diseases unrelated to Huntington's disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent the progression of Huntington's disease.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of Huntington's disease, but the specific role of the Rhes-SUMO pathway is still being explored.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Subramaniam, Srini — University of Florida
- Study coordinator: Subramaniam, Srini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.