Improving hepatitis C treatment in drug treatment clinics
Enhancing Treatment of Hepatitis C in Opioid Substitution Settings II (ETHOS II): A Partnership Project to Enhance Hepatitis C Care in Drug and Alcohol Clinics
This study is testing if providing hepatitis C testing and treatment directly at drug treatment clinics can help people who use drugs get better care for their hepatitis C.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 6000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Kirby Institute Government |
| Locations | 29 sites (Brookvale, New South Wales and 28 other locations) |
| Trial ID | NCT03685045 on ClinicalTrials.gov |
What this trial studies
The ETHOS ENGAGE project aims to enhance hepatitis C virus (HCV) care in drug treatment clinics and needle and syringe programs across New South Wales, Australia. This non-randomised trial will assess the impact of on-site HCV RNA testing, liver fibrosis assessment, and linkage to care to improve access to direct-acting antiviral therapy for individuals with a history of injecting drug use. Participants will also complete a survey and may consent to link their data with existing population databases for comprehensive analysis. The project is part of a larger initiative to develop a framework for HCV screening and treatment in similar settings nationwide.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18 and older with a history of injecting drug use, recent injecting drug use, or those currently receiving opioid substitution therapy.
Not a fit: Patients who do not have a history of injecting drug use or are not receiving opioid substitution therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this project could significantly improve access to effective hepatitis C treatment for vulnerable populations.
How similar studies have performed: Other studies have shown success in enhancing HCV treatment access in similar populations, indicating a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant has voluntarily signed the informed consent form; * 18 years of age or older; * History of injecting drug use\*; * Recent injecting drug use (previous six months) or currently receiving OST\*. * These criteria will not apply for recruitment from residential rehabilitation centres Exclusion Criteria: * Nil
Where this trial is running
Brookvale, New South Wales and 28 other locations
- NSLHD Brookvale Community Health Centre — Brookvale, New South Wales, Australia (Recruiting)
- Coopers Cottage, Campbelltown Drug Health Services — Campbelltown, New South Wales, Australia (Recruiting)
- HNELHD Drug and Alcohol Clinical Services Cessnock — Cessnock, New South Wales, Australia (Not_yet_recruiting)
- MNCLHD Coffs Harbour Alcohol and Other Drug Services — Coffs Harbour, New South Wales, Australia (Recruiting)
- Rankin Court Treatment Centre — Darlinghurst, New South Wales, Australia (Recruiting)
- NNSWLHD Grafton Alcohol and Other Drug Services — Grafton, New South Wales, Australia (Not_yet_recruiting)
- NBMLHD Drug & Alcohol Services Katoomba — Katoomba, New South Wales, Australia (Recruiting)
- MNCLHD Kempsey Alcohol and Other Drug Services — Kempsey, New South Wales, Australia (Recruiting)
- NBMLHD Drug & Alcohol Services Nepean — Kingswood, New South Wales, Australia (Recruiting)
- NNSWLHD Lismore (Riverlands) Alcohol and Other Drug Services — Lismore, New South Wales, Australia (Recruiting)
- NBMLHD Drug & Alcohol Services Lithgow — Lithgow, New South Wales, Australia (Recruiting)
- Liverpool Opioid Treatment Program — Liverpool, New South Wales, Australia (Recruiting)
- WSLHD Mount Druitt Drug Health OST Clinic — Mount Druitt, New South Wales, Australia (Recruiting)
- HNELHD Drug and Alcohol Clinical Services Newcastle — Newcastle, New South Wales, Australia (Recruiting)
- Lawrence Avenue Methadone Program (LAMP) — Nowra, New South Wales, Australia (Recruiting)
- WSLHD Fleet Street Drug Health OST Clinic — Parramatta, New South Wales, Australia (Recruiting)
- MNCLHD Port Macquarie Alcohol and Other Drug Services — Port Macquarie, New South Wales, Australia (Recruiting)
- NSLHD Herbert Street Clinic — Saint Leonards, New South Wales, Australia (Recruiting)
- HNELHD Drug and Alcohol Clinical Services Tamworth — Tamworth, New South Wales, Australia (Not_yet_recruiting)
- HNELHD Drug and Alcohol Clinical Services Taree — Taree, New South Wales, Australia (Not_yet_recruiting)
- NNSWLHD Tweed Heads Alcohol and Other Drug Services — Tweed Heads, New South Wales, Australia (Not_yet_recruiting)
- The Orana Centre — Wollongong, New South Wales, Australia (Recruiting)
- Roma Street Clinic — Brisbane, Queensland, Australia (Recruiting)
- Youthlink — Cairns, Queensland, Australia (Recruiting)
- Northern Drug and Alcohol Services South Australia (DASSA) — Elizabeth, South Australia, Australia (Recruiting)
- Central Drug and Alcohol Services South Australia (DASSA) — Stepney, South Australia, Australia (Recruiting)
- Next Step Fremantle — Fremantle, Western Australia, Australia (Recruiting)
- Next Step Joondalup — Joondalup, Western Australia, Australia (Recruiting)
- Next Step East Perth — Perth, Western Australia, Australia (Recruiting)
Study contacts
- Study coordinator: David Silk, BSc
- Email: dsilk@kirby.unsw.edu.au
- Phone: +61 2 9385 0878
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.