Using hearts from donors with active hepatitis C (HCV NAT+) for transplantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational registry of patients who received proven HCV NAT+ donor hearts, including re-transplant recipients, with multi-organ transplants excluded. The study will collect clinical safety and outcome data such as survival, coronary allograft vasculopathy, and antiviral treatment use following transplantation. It builds on the availability of nucleic-acid testing (NAT) for donors and the widespread use of well-tolerated direct-acting antivirals (DAAs) to treat donor-derived HCV. Data will be analyzed to see whether current practices using HCV NAT+ donor hearts produce acceptable short- and medium-term outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Recipient of a proven HCV NAT+ donor heart.
2. Re-transplant patients will be included.

Exclusion Criteria:

1\. Multi-organ transplantation

Where it's running

• Baylor Scott & White Health Research Institute
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Shelley A Hall, MD FACC — Bswri
• Study coordinator: Joost Felius, PhD
• Email: Joost.Felius@BSWHEALTH.ORG
• Phone: 214-818-8943

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Transplanting abdominal wall tissue to repair defects

  This study is testing if transplanting abdominal wall tissue can safely fix defects in the abdominal area for people who need it.

  Recruiting Duke University · Durham, North Carolina · NCT03310905

• XVIVO Heart Box non-ischemic preservation for transporting donor hearts.

  This program tests whether the XVIVO non-ischemic heart preservation system can safely preserve extended-criteria donor hearts for adults waiting for a heart transplant.

  Recruiting at 14 sites XVIVO Perfusion · La Jolla, California and 13 other locations · NCT06895070

• High intensity interval training for pediatric heart transplant recipients

  This study is testing a 12-week home workout program to see if it can help kids who have had a heart transplant get stronger and feel better.

  Recruiting University of Alberta · Edmonton, Alberta · NCT05451979

• How cardiopulmonary exercise affects AlloSure donor-derived cell-free DNA in heart transplant recipients

  This will test whether exercise changes donor-derived cell-free DNA measured by AlloSure in people who have had heart transplants.

  Recruiting Baylor Research Institute · Dallas, Texas · NCT04656080

• Glecaprevir/pibrentasvir started during pregnancy for women with hepatitis C, with or without HIV

  This trial will test whether taking glecaprevir/pibrentasvir during pregnancy is safe and how the drug is processed in pregnant women who have hepatitis C, including those who also have HIV, and will follow their infants for 10 weeks after birth.

  Recruiting at 8 sites Phase 1/2 National Institute of Allergy and Infectious Diseases (NIAID) · Los Angeles, California and 9 other locations · NCT07040319

• Assessing diabetes risk in cirrhosis patients before and after liver transplant

  This study is trying to find out what factors might lead to diabetes in adults with liver cirrhosis before and after they get a liver transplant.

  Recruiting University of Chicago · Chicago, Illinois · NCT06950788

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.