Investigating how the immune system responds to hepatitis C virus after treatment
Understanding human antibody responses to chronic viral hepatitis C
This study is looking at how the immune system remembers the hepatitis C virus after treatment, to help understand why some people might get reinfected and to improve vaccines for those at higher risk, and we’d love for patients to help by sharing samples for this important research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11005205 on NIH RePORTER |
What this research studies
This research focuses on understanding the immune memory of patients who have been treated for chronic hepatitis C virus (HCV) infection. It aims to explore how the immune system, particularly memory B cells, responds to HCV after successful treatment with direct-acting antivirals (DAAs). By studying these immune responses, the research seeks to identify why some patients are at risk of reinfection and how to improve vaccine strategies for high-risk populations. Patients may be involved in providing samples to help track these immune responses over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been treated for chronic hepatitis C and are interested in understanding their immune response.
Not a fit: Patients who have never been infected with hepatitis C or those who are not interested in participating in research may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies and better protection for individuals at risk of hepatitis C reinfection.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Law, Mansun — Scripps Research Institute, the
- Study coordinator: Law, Mansun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.