Investigating how the immune system responds to hepatitis C virus after treatment
Official title: Understanding human antibody responses to chronic viral hepatitis C
Funded at Scripps Research Institute, the · NIH-11005205 · Data updated 2026-11-12
This study is looking at how the immune system remembers the hepatitis C virus after treatment, to help understand why some people might get reinfected and to improve vaccines for those at higher risk, and we’d love for patients to help by sharing samples for this important research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | January 17, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $618,099 |
| NIH project number | 5R01AI168917-04 |
| Project ID | NIH-11005205 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been treated for chronic hepatitis C and are interested in understanding their immune response.
✕Less likely to help
Patients who have never been infected with hepatitis C or those who are not interested in participating in research may not benefit from this study.
What this research studies
This research focuses on understanding the immune memory of patients who have been treated for chronic hepatitis C virus (HCV) infection. It aims to explore how the immune system, particularly memory B cells, responds to HCV after successful treatment with direct-acting antivirals (DAAs). By studying these immune responses, the research seeks to identify why some patients are at risk of reinfection and how to improve vaccine strategies for high-risk populations. Patients may be involved in providing samples to help track these immune responses over time.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies and better protection for individuals at risk of hepatitis C reinfection.
How similar studies have gone: Previous research has shown promising results in understanding immune responses to viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Law, Mansun — Scripps Research Institute, the
- Study coordinator: Law, Mansun
Related research
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-
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A small, patient-focused study will look at how HIV, hepatitis C, and other sexually transmitted infections occur together in rural people who inject drugs during an HIV outbreak, and what factors relate to these co-infections.
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Aiming to provide a fast, easy blood test to detect hepatitis C right where care is delivered.
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Hepatitis C screening tool used in the Emergency Department
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.