Developing a vaccine to protect against hepatitis C virus infection
SELECTION OF VACCINE ANTIGENS FOR PROTECTION FROM HEPATITIS C VIRUS INFECTION
This study is testing a new vaccine designed to help protect people from hepatitis C, a virus that can cause serious liver problems, by boosting their immune response to prevent reinfection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10836046 on NIH RePORTER |
What this research studies
This research focuses on creating a vaccine to protect against hepatitis C virus (HCV) infection, which can lead to severe liver disease. The approach involves modifying the HCV envelope glycoprotein to enhance immune responses and prevent reinfection. By using advanced techniques like nucleoside modified mRNA-lipid nanoparticles, the researchers aim to stimulate a stronger immune reaction in patients. The study will assess the safety and effectiveness of this vaccine candidate in generating protective immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk of hepatitis C virus infection or those who have previously been infected.
Not a fit: Patients who are already infected with hepatitis C and have progressed to end-stage liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a vaccine that prevents hepatitis C virus infection and its associated liver diseases.
How similar studies have performed: Other research has shown promise in developing vaccines for viral infections, but this specific approach is novel and untested.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ray, Ranjit — Saint Louis University
- Study coordinator: Ray, Ranjit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.