Understanding how Hepatitis C virus RNA interacts with itself
Official title: Uncovering the Biochemical Mechanisms of Riboregulatory Interaction Involving the Hepatitis C Virus 3'X RNA
Funded at University of Kansas Lawrence · NIH-10937178 · Data updated 2026-11-12
This study is looking at how certain parts of the Hepatitis C virus communicate with each other, which could help us find better ways to treat the virus and improve outcomes for people living with Hepatitis C.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $376,738 |
| NIH project number | 1R35GM154858-01 |
| Project ID | NIH-10937178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Hepatitis C who may benefit from advancements in treatment options.
✕Less likely to help
Patients with other viral infections or those who do not have Hepatitis C may not receive any benefit from this research.
What this research studies
This research investigates the biochemical mechanisms behind the interactions of specific RNA elements within the Hepatitis C virus (HCV). By focusing on the 3'X RNA, which plays a crucial role in regulating viral processes such as replication and translation, the study aims to uncover how these RNA elements communicate with each other. The approach involves analyzing the structural and energetic properties of these RNA interactions to better understand their impact on the virus's lifecycle. This knowledge could lead to improved strategies for targeting HCV and enhancing treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Hepatitis C by targeting the virus's RNA interactions.
How similar studies have gone: While there has been significant research on HCV, the specific biochemical mechanisms of RNA interactions being investigated in this project are relatively novel.
Where this research is happening
-
University of Kansas Lawrence
Lawrence, United States Active
Researchers
- Principal investigator: Holmstrom, Erik D — University of Kansas Lawrence
- Study coordinator: Holmstrom, Erik D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.