Condition

Helicobacter Pylori Infection clinical trials and research

• 28Clinical trials
• 11NIH research projects
• 10Countries

Newest Helicobacter Pylori Infection clinical trials

All recruiting trials (28)

• Fecal transplant to help eradicate stubborn Helicobacter pylori infection

  This study tests whether giving a fecal microbiota transplant can help people with Helicobacter pylori infection that has not responded to standard treatments.

  Recruiting Phase 4 Sichuan Provincial People's Hospital · Chengdu, Sichuan · NCT07704255

• Fecal-guided simplified vonoprazan plus clarithromycin first-line therapy for H. pylori

  We are testing whether a two-drug regimen of vonoprazan plus clarithromycin clears H. pylori in adults whose fecal PCR shows no clarithromycin resistance mutations.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07439445

• Bismuth-amoxicillin-vonoprazan triple therapy versus bismuth-based quadruple therapy for H. pylori infection

  This will test whether a 14-day bismuth-amoxicillin-vonoprazan triple therapy works better and is as safe as a 14-day bismuth-based quadruple therapy for adults with H. pylori infection.

  Recruiting Kaohsiung Medical University · Kaohsiung City · NCT07358130

• P-CABs plus bismuth quadruple treatment for Helicobacter pylori infection

  This study tests whether using potassium-competitive acid blockers (P-CABs) in bismuth-containing quadruple therapy works better and is safe for adults with H. pylori infection.

  Recruiting Qilu Hospital of Shandong University · Jinan · NCT07285096

• Bismuth versus no bismuth for treating H. pylori-related stomach and duodenal ulcers in children

  This project will try adding bismuth to standard antibiotic and PPI treatment to see if it helps clear H. pylori and heal ulcers in children.

  Recruiting Can Tho University of Medicine and Pharmacy · Can Tho · NCT07260006

• Tegoprazan 50 mg twice daily plus amoxicillin versus vonoprazan 20 mg twice daily plus amoxicillin for H. pylori eradication

  This trial tests whether a 14-day tegoprazan plus amoxicillin regimen works as well as a vonoprazan plus amoxicillin regimen to cure Helicobacter pylori infection in adults.

  Recruiting Phase 2/3 First People's Hospital of Hangzhou · Hangzhou, Zhejiang · NCT07242456

• Potassium-competitive acid blocker versus proton pump inhibitor with bismuth quadruple therapy for H. pylori infection

  This trial tests whether a potassium-competitive acid blocker works better than a proton pump inhibitor as part of bismuth quadruple therapy to cure H. pylori infection in adults.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07165444

• Adding Saccharomyces boulardii to bismuth quadruple therapy for H. pylori rescue

  This tests whether adding the probiotic Saccharomyces boulardii to bismuth-containing quadruple therapy helps adults whose H. pylori infection did not clear after prior treatments.

  Recruiting Phase 4 Xijing Hospital of Digestive Diseases · Xi'an, Shaanxi · NCT07139366

• Vonoprazan versus standard triple therapy for H. pylori eradication

  This trial tests whether a vonoprazan-based regimen clears H. pylori better than standard proton-pump-inhibitor triple therapy in adults with confirmed H. pylori infection and dyspepsia or peptic ulcers.

  Recruiting Phase 4 Asian Institute of Gastroenterology, India · Hyderabad, Telangana · NCT06959368

• New treatment approach for Helicobacter pylori infection

  This study is testing a new two-phase treatment for Helicobacter pylori infection that combines a stomach medication with higher doses of antibiotics to see if it works better and is easier for patients to handle than the usual treatment.

  Recruiting Phase 4 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06929962

• Examining the safety of vonoprazan in pregnant women and their babies

  This study is testing whether taking vonoprazan during pregnancy is safe for both mothers and their babies by comparing outcomes between those who took the medication and those who didn’t.

  Recruiting Phathom Pharmaceuticals, Inc. · Wilmington, North Carolina · NCT06660342

• Eradicating H. Pylori with Argon Plasma During Endoscopy

  This study is testing a new argon plasma treatment during endoscopy to see if it can safely get rid of H. pylori infections in patients who haven't been treated yet.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06529159

• Investigating the effects of treating Helicobacter Pylori on dyspepsia symptoms

  This study is testing if treating Helicobacter pylori can help people with upset stomach symptoms feel better over time.

  Recruiting at 26 sites Shanghai Jiao Tong University School of Medicine · Chongqing, Chongqing Municipality and 25 other locations · NCT06422052

• AI-guided health recommendations for gastric cancer prevention

  This study is testing an AI tool that helps doctors spot early signs of stomach issues and gives personalized advice to prevent gastric cancer.

  Recruiting Fundación para la Investigación del Hospital Clínico de Valencia · Valencia · NCT06421324

• New treatment for Helicobacter Pylori infection using tegoprazan

  This study is testing a new 10-day treatment using tegoprazan to see if it can more effectively get rid of Helicobacter pylori infections compared to the usual treatment with esomeprazole.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT06382493

• Treatment of HP-positive gastric MALT lymphoma with Orelabrutinib

  This study is testing if a new treatment called Orelabrutinib, combined with standard therapy for Helicobacter pylori, can help people with HP-positive gastric MALT lymphoma feel better compared to usual treatments.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06228963

• Eradication of Helicobacter Pylori in Adolescents in Chile

  This study is testing a new approach to treat Helicobacter pylori infections in healthy teenagers in Chile to see if it can help prevent future health problems like stomach cancer.

  Recruiting at 3 sites University of Chile · Coyhaique and 2 other locations · NCT05926804

• Using doxycycline to treat Helicobacter pylori infections

  This study is testing if a new 14-day treatment using doxycycline can effectively help people with Helicobacter pylori infections who haven't responded to previous treatments.

  Recruiting Phase 4 Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT05874570

• Using AI to diagnose Helicobacter Pylori infection and gastric lesions

  This study is testing whether artificial intelligence can help doctors in rural areas diagnose Helicobacter pylori infections and early signs of stomach cancer by looking at images from endoscopies.

  Recruiting National Taiwan University Hospital · Taipei · NCT05762991

• Testing the effectiveness of the PyloPlus Urea Breath Test for H. pylori after treatment

  This study is testing if the PyloPlus Urea Breath Test can accurately confirm that people who have been treated for H. pylori no longer have the infection.

  Recruiting at 2 sites Phase 3 ARJ Medical, Inc. · Doral, Florida and 1 other locations · NCT05681689

• Assessing H. pylori infection rates and antibiotic resistance in Germany

  This study is trying to find out how common H. pylori infections are in Germany and if the bacteria are resistant to antibiotics, so doctors can better treat patients.

  Recruiting Technical University of Munich · Munich · NCT05561504

• Comparing tailored therapy to standard treatment for Helicobacter pylori infection

  This study is testing if a personalized treatment plan for Helicobacter pylori infection works better than the standard treatment for people who haven't had success with previous therapies.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT05332444

• Assessing antibiotic resistance in Helicobacter pylori in Korea

  This study looks at how common antibiotic resistance is in Helicobacter pylori bacteria from patients with stomach issues in Korea to help improve treatment options.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT05247112

• Understanding how Helicobacter pylori affects the gut microbiome

  This study looks at how an infection with Helicobacter pylori affects the gut bacteria in people to see if these changes can help predict how severe the infection is and how well treatments work.

  Recruiting University Hospital Freiburg · Freiburg im Breisgau, Baden-Wurttemberg · NCT05121025

• Dual H. pylori eradication versus proton pump inhibitor to prevent gastrointestinal bleeding in heart-attack patients on dual antiplatelet therapy

  This trial tests whether a two-week vonoprazan-plus-amoxicillin H. pylori eradication regimen lowers gastrointestinal bleeding compared with standard PPI use in adults with acute coronary syndrome who are H. pylori–positive and on dual antiplatelet therapy after stenting.

  Recruiting at 26 sites Phase 4 Qilu Hospital of Shandong University · Bozhou, Anhui and 41 other locations · NCT04728516

• Treatment of Helicobacter Pylori Infection in Children with Nitazoxanide

  This study is testing a new combination treatment for Helicobacter pylori infections in children to see if it works better than current options.

  Recruiting Phase 3 Tanta University · Tanta · NCT04415983

• Targeted versus standard therapy for stubborn H. pylori infections

  This trial will test whether choosing antibiotics based on lab susceptibility results works better than standard empirical therapy for adults whose H. pylori infection did not clear after at least two prior treatments.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT04332848

• Observational study on gastric precancerous conditions

  This study looks at people who are at higher risk for stomach cancer to see how conditions like atrophic gastritis and intestinal metaplasia develop over time.

  Recruiting Stanford University · Stanford, California · NCT04191551

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how Helicobacter pylori causes disease and how to block it

  Scientists are studying how the stomach-dwelling bacteria H. pylori causes illness and how to stop it from using its outer proteins to grab nutrients.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11401616

• Genetic factors shaping Helicobacter pylori infection

  A scientist is studying how the genetics of the stomach bacterium Helicobacter pylori interact with human hosts to influence infection and disease risk.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11390410

• Family-based testing to prevent gastric cancer from Helicobacter pylori

  A doctor-facing plan to test and treat multiple family members of someone with H. pylori to prevent stomach cancer in adults.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11337853

• New cancer-causing mechanisms in H. pylori infection

  A scientist is studying how Helicobacter pylori may cause stomach cancer and how this knowledge could lead to better treatments for patients.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11330681

• How H. pylori infection may cause stomach inflammation and early cancer changes

  This project looks at how H. pylori infection together with an activated cancer-related gene (KRAS) changes stomach cells toward precancerous and cancerous states, mainly using mouse models.

  NIH research Purdue University · West Lafayette, United States · NIH-11257317

• How H. pylori causes stomach infection and disease

  This project looks at bacterial proteins that help H. pylori survive in the stomach to help people with H. pylori infections and related ulcers or cancer risk.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11116982

• Investigating how polyamines affect stomach cancer risk during H. pylori infection

  This study is looking at how certain natural compounds in the stomach might affect inflammation and the risk of stomach cancer in people infected with Helicobacter pylori, and it aims to find new ways to help prevent cancer for those individuals.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11061355

• Understanding how Helicobacter pylori infection leads to stomach inflammation and cancer risk

  This study is looking at how a germ called Helicobacter pylori, which can cause long-term stomach problems, might help lead to stomach cancer, using mice to learn more about how the body reacts to this germ and what changes happen in the stomach cells, with hopes of finding better ways to prevent or treat stomach cance

  NIH research Purdue University · West Lafayette, United States · NIH-11032897

• Understanding how H. pylori bacteria cause stomach problems

  This research explores the genetic makeup of H. pylori bacteria to understand how they cause long-term stomach infections and lead to serious conditions like ulcers and stomach cancer.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11012785

• Understanding how Helicobacter pylori bacteria affect stomach health

  This study is looking at how a stomach bacteria called Helicobacter pylori uses certain proteins to survive and cause problems like ulcers and cancer, with the hope of finding new ways to prevent and treat infections for people affected by it.

  NIH research Veterans Health Administration · Nashville, United States · NIH-10918527

• How H. pylori infection affects ribosomal proteins in the body

  This study is looking at how an infection with Helicobacter pylori affects certain proteins in your body, which could help us understand more about the health problems linked to this infection.

  NIH research Yale University · New Haven, United States · NIH-10823409

Related topics

Quick answers

How many Helicobacter Pylori Infection clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in China (10 trials), Taiwan (4 trials), United States (4 trials), Egypt (2 trials), South Korea (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 8, Phase 3: 2, Phase 2/3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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