Understanding how Helicobacter pylori infection leads to stomach inflammation and cancer risk
Official title: Investigating gastric inflammation and preneoplastic progression driven by Helicobacter pylori infection
Funded at Purdue University · NIH-11032897 · Data updated 2026-11-12
This study is looking at how a germ called Helicobacter pylori, which can cause long-term stomach problems, might help lead to stomach cancer, using mice to learn more about how the body reacts to this germ and what changes happen in the stomach cells, with hopes of finding better ways to prevent or treat stomach cancer in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | July 7, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $122,717 |
| NIH project number | 5R00CA263036-04 |
| Project ID | NIH-11032897 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of Helicobacter pylori infection or those at risk for gastric cancer due to chronic inflammation.
✕Less likely to help
Patients who do not have Helicobacter pylori infection or those with unrelated gastrointestinal conditions may not benefit from this research.
What this research studies
This research investigates the role of Helicobacter pylori, a bacterium that causes chronic stomach inflammation, in the progression of gastric cancer. By studying a mouse model with specific genetic alterations, the researchers aim to uncover how this infection triggers changes in stomach cells that can lead to cancer. The study focuses on the immune response and cellular changes that occur due to the infection, which may provide insights into preventing or treating gastric cancer in humans.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing gastric cancer in individuals infected with Helicobacter pylori.
How similar studies have gone: Previous research has shown that chronic inflammation from infections can lead to cancer, suggesting that this approach may yield valuable insights into gastric cancer mechanisms.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: O'brien, Valerie Phoebe — Purdue University
- Study coordinator: O'brien, Valerie Phoebe
Related research
Other NIH-funded projects on the same topics.
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Understanding how Helicobacter pylori causes disease and how to block it
Scientists are studying how the stomach-dwelling bacteria H. pylori causes illness and how to stop it from using its outer proteins to grab nutrients.
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Genetic factors shaping Helicobacter pylori infection
A scientist is studying how the genetics of the stomach bacterium Helicobacter pylori interact with human hosts to influence infection and disease risk.
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Family-based testing to prevent gastric cancer from Helicobacter pylori
A doctor-facing plan to test and treat multiple family members of someone with H. pylori to prevent stomach cancer in adults.
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New cancer-causing mechanisms in H. pylori infection
A scientist is studying how Helicobacter pylori may cause stomach cancer and how this knowledge could lead to better treatments for patients.
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How H. pylori infection may cause stomach inflammation and early cancer changes
This project looks at how H. pylori infection together with an activated cancer-related gene (KRAS) changes stomach cells toward precancerous and cancerous states, mainly using mouse models.
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How H. pylori causes stomach infection and disease
This project looks at bacterial proteins that help H. pylori survive in the stomach to help people with H. pylori infections and related ulcers or cancer risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.