Understanding how Helicobacter pylori infection leads to stomach inflammation and cancer risk
Investigating gastric inflammation and preneoplastic progression driven by Helicobacter pylori infection
This study is looking at how a germ called Helicobacter pylori, which can cause long-term stomach problems, might help lead to stomach cancer, using mice to learn more about how the body reacts to this germ and what changes happen in the stomach cells, with hopes of finding better ways to prevent or treat stomach cancer in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11032897 on NIH RePORTER |
What this research studies
This research investigates the role of Helicobacter pylori, a bacterium that causes chronic stomach inflammation, in the progression of gastric cancer. By studying a mouse model with specific genetic alterations, the researchers aim to uncover how this infection triggers changes in stomach cells that can lead to cancer. The study focuses on the immune response and cellular changes that occur due to the infection, which may provide insights into preventing or treating gastric cancer in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of Helicobacter pylori infection or those at risk for gastric cancer due to chronic inflammation.
Not a fit: Patients who do not have Helicobacter pylori infection or those with unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing gastric cancer in individuals infected with Helicobacter pylori.
How similar studies have performed: Previous research has shown that chronic inflammation from infections can lead to cancer, suggesting that this approach may yield valuable insights into gastric cancer mechanisms.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: O'brien, Valerie Phoebe — Purdue University
- Study coordinator: O'brien, Valerie Phoebe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.