Investigating how polyamines affect stomach cancer risk during H. pylori infection
Polyamine Dysregulation in the Gastric Epithelium during Helicobacter pylori Infection and its Impact on Gastric Carcinogenesis
This study is looking at how certain natural compounds in the stomach might affect inflammation and the risk of stomach cancer in people infected with Helicobacter pylori, and it aims to find new ways to help prevent cancer for those individuals.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11061355 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of polyamines in the stomach during infection with Helicobacter pylori, a bacteria linked to gastric cancer. The study examines how these compounds, particularly putrescine, spermidine, and spermine, influence inflammation and the progression of gastric diseases. By using mouse models, researchers are exploring how changes in polyamine levels can affect the development of precancerous lesions and cancer itself. The goal is to identify new therapeutic strategies to prevent gastric cancer in individuals infected with H. pylori.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a confirmed Helicobacter pylori infection, particularly those showing early signs of gastric inflammation or precancerous lesions.
Not a fit: Patients who do not have a Helicobacter pylori infection or those with advanced gastric cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of gastric cancer in patients infected with H. pylori.
How similar studies have performed: Previous research has shown promising results in understanding the role of polyamines in cancer development, suggesting that this approach could yield significant insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Mcnamara, Kara — Vanderbilt University
- Study coordinator: Mcnamara, Kara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.