Investigating how polyamines affect stomach cancer risk during H. pylori infection
Official title: Polyamine Dysregulation in the Gastric Epithelium during Helicobacter pylori Infection and its Impact on Gastric Carcinogenesis
Funded at Vanderbilt University · NIH-11061355 · Data updated 2026-11-12
This study is looking at how certain natural compounds in the stomach might affect inflammation and the risk of stomach cancer in people infected with Helicobacter pylori, and it aims to find new ways to help prevent cancer for those individuals.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | May 1, 2023 |
| Project end | May 12, 2025 |
| Funding year | 2025 |
| Award (this year) | $4,627 |
| NIH project number | 5F31CA278330-03 |
| Project ID | NIH-11061355 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a confirmed Helicobacter pylori infection, particularly those showing early signs of gastric inflammation or precancerous lesions.
✕Less likely to help
Patients who do not have a Helicobacter pylori infection or those with advanced gastric cancer may not benefit from this research.
What this research studies
This research focuses on understanding the role of polyamines in the stomach during infection with Helicobacter pylori, a bacteria linked to gastric cancer. The study examines how these compounds, particularly putrescine, spermidine, and spermine, influence inflammation and the progression of gastric diseases. By using mouse models, researchers are exploring how changes in polyamine levels can affect the development of precancerous lesions and cancer itself. The goal is to identify new therapeutic strategies to prevent gastric cancer in individuals infected with H. pylori.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of gastric cancer in patients infected with H. pylori.
How similar studies have gone: Previous research has shown promising results in understanding the role of polyamines in cancer development, suggesting that this approach could yield significant insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Mcnamara, Kara — Vanderbilt University
- Study coordinator: Mcnamara, Kara
Related research
Other NIH-funded projects on the same topics.
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Understanding how Helicobacter pylori causes disease and how to block it
Scientists are studying how the stomach-dwelling bacteria H. pylori causes illness and how to stop it from using its outer proteins to grab nutrients.
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Genetic factors shaping Helicobacter pylori infection
A scientist is studying how the genetics of the stomach bacterium Helicobacter pylori interact with human hosts to influence infection and disease risk.
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Family-based testing to prevent gastric cancer from Helicobacter pylori
A doctor-facing plan to test and treat multiple family members of someone with H. pylori to prevent stomach cancer in adults.
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New cancer-causing mechanisms in H. pylori infection
A scientist is studying how Helicobacter pylori may cause stomach cancer and how this knowledge could lead to better treatments for patients.
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How H. pylori infection may cause stomach inflammation and early cancer changes
This project looks at how H. pylori infection together with an activated cancer-related gene (KRAS) changes stomach cells toward precancerous and cancerous states, mainly using mouse models.
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How H. pylori causes stomach infection and disease
This project looks at bacterial proteins that help H. pylori survive in the stomach to help people with H. pylori infections and related ulcers or cancer risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.