New cancer-causing mechanisms in H. pylori infection
Official title: New carcinogenic mechanisms of Helicobacter pylori infection
Funded at University of Miami School of Medicine · NIH-11330681 · Data updated 2026-11-12
A scientist is studying how Helicobacter pylori may cause stomach cancer and how this knowledge could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 1, 2010 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $390,090 |
| NIH project number | 5R01CA138833-13 |
| Project ID | NIH-11330681 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with gastric cancer or gastritis related to H. pylori infection, or individuals at risk due to infection.
✕Less likely to help
Healthy individuals without H. pylori infection or gastric cancer are unlikely to benefit directly.
What this research studies
This project looks at how H. pylori infections contribute to gastric cancer by studying the roles of specific proteins and bacterial factors. Researchers will use patient-derived stomach cells, organoids, and animal models to understand how these bacteria interact with human tissue to promote cancer. The goal is to uncover targets that could lead to new therapies or prevention strategies for people with H. pylori-related gastric cancer.
Why it matters
Potential benefit: If successful, the work could identify new targets for therapies to prevent or treat gastric cancer linked to H. pylori infection.
How similar studies have gone: Previous studies have linked H. pylori factors to gastric carcinogenesis, but the exact mechanisms and targets are still being explored, making this a promising but not yet proven approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Zaika, Alexander I. — University of Miami School of Medicine
- Study coordinator: Zaika, Alexander I.
Related research
Other NIH-funded projects on the same topics.
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Understanding how Helicobacter pylori causes disease and how to block it
Scientists are studying how the stomach-dwelling bacteria H. pylori causes illness and how to stop it from using its outer proteins to grab nutrients.
-
Genetic factors shaping Helicobacter pylori infection
A scientist is studying how the genetics of the stomach bacterium Helicobacter pylori interact with human hosts to influence infection and disease risk.
-
Family-based testing to prevent gastric cancer from Helicobacter pylori
A doctor-facing plan to test and treat multiple family members of someone with H. pylori to prevent stomach cancer in adults.
-
How H. pylori infection may cause stomach inflammation and early cancer changes
This project looks at how H. pylori infection together with an activated cancer-related gene (KRAS) changes stomach cells toward precancerous and cancerous states, mainly using mouse models.
-
How H. pylori causes stomach infection and disease
This project looks at bacterial proteins that help H. pylori survive in the stomach to help people with H. pylori infections and related ulcers or cancer risk.
-
Investigating how polyamines affect stomach cancer risk during H. pylori infection
This study is looking at how certain natural compounds in the stomach might affect inflammation and the risk of stomach cancer in people infected with Helicobacter pylori, and it aims to find new ways to help prevent cancer for those individuals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.