Understanding how Helicobacter pylori bacteria affect stomach health
"Pathogenesis of Helicobacter pylori Infection"
This study is looking at how a stomach bacteria called Helicobacter pylori uses certain proteins to survive and cause problems like ulcers and cancer, with the hope of finding new ways to prevent and treat infections for people affected by it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10918527 on NIH RePORTER |
What this research studies
This research investigates the role of Helicobacter pylori, a bacterium that colonizes the stomach and is linked to serious conditions like gastric cancer and peptic ulcers. The study focuses on specific proteins produced by H. pylori that may help the bacteria acquire essential nutrients, which could influence its ability to cause disease. By analyzing genetic mutations in these proteins, researchers aim to uncover how H. pylori interacts with the stomach environment and contributes to health issues. This work could lead to new strategies for prevention and treatment of infections caused by this bacterium.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with H. pylori infection or those at risk for gastric cancer and peptic ulcers.
Not a fit: Patients who do not have H. pylori infection or are not at risk for related gastric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for gastric cancer and peptic ulcers associated with H. pylori infection.
How similar studies have performed: Previous research has shown that understanding bacterial mechanisms can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Cover, Timothy L — Veterans Health Administration
- Study coordinator: Cover, Timothy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.