Understanding how Helicobacter pylori bacteria affect stomach health
Official title: "Pathogenesis of Helicobacter pylori Infection"
Funded at Veterans Health Administration · NIH-10918527 · Data updated 2026-11-12
This study is looking at how a stomach bacteria called Helicobacter pylori uses certain proteins to survive and cause problems like ulcers and cancer, with the hope of finding new ways to prevent and treat infections for people affected by it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2019 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 2I01BX004447-05A2 |
| Project ID | NIH-10918527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with H. pylori infection or those at risk for gastric cancer and peptic ulcers.
✕Less likely to help
Patients who do not have H. pylori infection or are not at risk for related gastric conditions may not benefit from this research.
What this research studies
This research investigates the role of Helicobacter pylori, a bacterium that colonizes the stomach and is linked to serious conditions like gastric cancer and peptic ulcers. The study focuses on specific proteins produced by H. pylori that may help the bacteria acquire essential nutrients, which could influence its ability to cause disease. By analyzing genetic mutations in these proteins, researchers aim to uncover how H. pylori interacts with the stomach environment and contributes to health issues. This work could lead to new strategies for prevention and treatment of infections caused by this bacterium.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for gastric cancer and peptic ulcers associated with H. pylori infection.
How similar studies have gone: Previous research has shown that understanding bacterial mechanisms can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Cover, Timothy L — Veterans Health Administration
- Study coordinator: Cover, Timothy L
Related research
Other NIH-funded projects on the same topics.
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Understanding how Helicobacter pylori causes disease and how to block it
Scientists are studying how the stomach-dwelling bacteria H. pylori causes illness and how to stop it from using its outer proteins to grab nutrients.
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Genetic factors shaping Helicobacter pylori infection
A scientist is studying how the genetics of the stomach bacterium Helicobacter pylori interact with human hosts to influence infection and disease risk.
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Family-based testing to prevent gastric cancer from Helicobacter pylori
A doctor-facing plan to test and treat multiple family members of someone with H. pylori to prevent stomach cancer in adults.
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New cancer-causing mechanisms in H. pylori infection
A scientist is studying how Helicobacter pylori may cause stomach cancer and how this knowledge could lead to better treatments for patients.
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How H. pylori infection may cause stomach inflammation and early cancer changes
This project looks at how H. pylori infection together with an activated cancer-related gene (KRAS) changes stomach cells toward precancerous and cancerous states, mainly using mouse models.
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How H. pylori causes stomach infection and disease
This project looks at bacterial proteins that help H. pylori survive in the stomach to help people with H. pylori infections and related ulcers or cancer risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.