How H. pylori infection affects ribosomal proteins in the body
Official title: Redox Regulation of Host Ribosomal Proteins during Helicobacter pylori infection
Funded at Yale University · NIH-10823409 · Data updated 2026-11-12
This study is looking at how an infection with Helicobacter pylori affects certain proteins in your body, which could help us understand more about the health problems linked to this infection.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,116 |
| NIH project number | 1F31AI176757-01A1 |
| Project ID | NIH-10823409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with H. pylori infection or related gastric conditions.
✕Less likely to help
Patients without H. pylori infection or those with unrelated gastric issues may not benefit from this research.
What this research studies
This research investigates the impact of Helicobacter pylori infection on ribosomal proteins in the human body. It focuses on understanding how the infection leads to the production of reactive oxygen species, which can modify proteins and affect their function. The study will specifically examine two ribosomal proteins, uL14 and eS27, to see how their activity changes during infection. By analyzing these changes, the research aims to uncover new insights into the mechanisms of H. pylori-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating gastric diseases associated with H. pylori infection.
How similar studies have gone: Previous research has shown that understanding the role of reactive oxygen species in infections can lead to significant advancements in treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Ramanathan, Renuka Ganesh — Yale University
- Study coordinator: Ramanathan, Renuka Ganesh
Related research
Other NIH-funded projects on the same topics.
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Understanding how Helicobacter pylori causes disease and how to block it
Scientists are studying how the stomach-dwelling bacteria H. pylori causes illness and how to stop it from using its outer proteins to grab nutrients.
-
Genetic factors shaping Helicobacter pylori infection
A scientist is studying how the genetics of the stomach bacterium Helicobacter pylori interact with human hosts to influence infection and disease risk.
-
Family-based testing to prevent gastric cancer from Helicobacter pylori
A doctor-facing plan to test and treat multiple family members of someone with H. pylori to prevent stomach cancer in adults.
-
New cancer-causing mechanisms in H. pylori infection
A scientist is studying how Helicobacter pylori may cause stomach cancer and how this knowledge could lead to better treatments for patients.
-
How H. pylori infection may cause stomach inflammation and early cancer changes
This project looks at how H. pylori infection together with an activated cancer-related gene (KRAS) changes stomach cells toward precancerous and cancerous states, mainly using mouse models.
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How H. pylori causes stomach infection and disease
This project looks at bacterial proteins that help H. pylori survive in the stomach to help people with H. pylori infections and related ulcers or cancer risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.