Understanding how Helicobacter pylori affects the gut microbiome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the interactions between Helicobacter pylori infection and the human gut microbiome. It aims to determine how changes in the microbiome, as measured through stool samples, can predict the severity of H. pylori-related diseases and treatment outcomes. The study will analyze the gut microbiome and immune responses in patients and healthy volunteers to uncover the mechanisms behind microbial imbalances caused by H. pylori. By exploring these relationships, the research seeks to provide insights into the role of the microbiome in H. pylori infections.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients: -

* Male and female patients aged ≥ 18 years.
* Specimens from patients undergoing tissue sampling, stool, and blood to rule out Helicobacter pylori infection
* Written informed consent from patients.

Volunteer subjects: -

* Male and female (non-pregnant) volunteers between the ages of 18-65 years.
* Written informed consent from volunteers.
* No acute medical conditions
* No regular medication use, and no antibiotic use in the last 4 weeks.

Exclusion Criteria:

Patients: -

* Minor patients
* Patients not capable of giving consent
* Samples without sufficient residual material after standard diagnostic procedures
* Samples from patients who have not given consent for testing

Volunteer subjects: -

* Subjects not capable of giving consent
* Subjects with acute illnesses
* Subjects older than 65 or younger than 18 years of age.
* Pregnant women

Where it's running

• Institute for Microbiology and Hygiene
  Freiburg im Breisgau, Baden-Wurttemberg, Germany Recruiting

Study contacts

• Study coordinator: Mohamed Tarek Badr, M.D.
• Email: mohamed.tarek.badr@uniklinik-freiburg.de
• Phone: 00497612036585

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Fecal transplant to help eradicate stubborn Helicobacter pylori infection

  This study tests whether giving a fecal microbiota transplant can help people with Helicobacter pylori infection that has not responded to standard treatments.

  Recruiting Phase 4 Sichuan Provincial People's Hospital · Chengdu, Sichuan · NCT07704255

• Fecal-guided simplified vonoprazan plus clarithromycin first-line therapy for H. pylori

  We are testing whether a two-drug regimen of vonoprazan plus clarithromycin clears H. pylori in adults whose fecal PCR shows no clarithromycin resistance mutations.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07439445

• Bismuth-amoxicillin-vonoprazan triple therapy versus bismuth-based quadruple therapy for H. pylori infection

  This will test whether a 14-day bismuth-amoxicillin-vonoprazan triple therapy works better and is as safe as a 14-day bismuth-based quadruple therapy for adults with H. pylori infection.

  Recruiting Kaohsiung Medical University · Kaohsiung City · NCT07358130

• P-CABs plus bismuth quadruple treatment for Helicobacter pylori infection

  This study tests whether using potassium-competitive acid blockers (P-CABs) in bismuth-containing quadruple therapy works better and is safe for adults with H. pylori infection.

  Recruiting Qilu Hospital of Shandong University · Jinan · NCT07285096

• Bismuth versus no bismuth for treating H. pylori-related stomach and duodenal ulcers in children

  This project will try adding bismuth to standard antibiotic and PPI treatment to see if it helps clear H. pylori and heal ulcers in children.

  Recruiting Can Tho University of Medicine and Pharmacy · Can Tho · NCT07260006

• Tegoprazan 50 mg twice daily plus amoxicillin versus vonoprazan 20 mg twice daily plus amoxicillin for H. pylori eradication

  This trial tests whether a 14-day tegoprazan plus amoxicillin regimen works as well as a vonoprazan plus amoxicillin regimen to cure Helicobacter pylori infection in adults.

  Recruiting Phase 2/3 First People's Hospital of Hangzhou · Hangzhou, Zhejiang · NCT07242456

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.