Understanding how H. pylori bacteria cause stomach problems
Genetic requirements of Helicobacter pylori infection
This research explores the genetic makeup of H. pylori bacteria to understand how they cause long-term stomach infections and lead to serious conditions like ulcers and stomach cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11012785 on NIH RePORTER |
What this research studies
Many people worldwide carry H. pylori bacteria in their stomach, which can cause inflammation and, for some, severe diseases like peptic ulcers and gastric cancer. This project looks at how these bacteria adapt genetically within the human stomach over time, especially as the stomach lining changes. We are also learning how H. pylori influences the body's immune response, which can contribute to chronic inflammation. By understanding these genetic and immune interactions, we hope to find new ways to prevent or treat H. pylori-related diseases.
Who could benefit from this research
Good fit: This research is relevant to individuals who have or are at risk for H. pylori infection, chronic stomach inflammation, peptic ulcers, or gastric adenocarcinoma.
Not a fit: Patients without H. pylori infection or related stomach conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better strategies for preventing and treating H. pylori infections and reducing the risk of stomach cancer.
How similar studies have performed: Previous work has shown that H. pylori adapts genetically during human infection and modulates the immune system, providing a foundation for this continued investigation.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Salama, Nina — Fred Hutchinson Cancer Center
- Study coordinator: Salama, Nina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.