How H. pylori causes stomach infection and disease
"Pathogenesis of Helicobacter pylori Infection"
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-11116982
This project looks at bacterial proteins that help H. pylori survive in the stomach to help people with H. pylori infections and related ulcers or cancer risk.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11116982 on ClinicalTrials.gov |
What this research studies
Researchers are studying specific outer membrane proteins in H. pylori that transport metals such as iron and nickel, which the bacteria need to live in the acidic stomach. They create bacterial strains with specific gene changes and test how those changes affect the bacteria's ability to take up metals and colonize. Lab experiments use cultured bacteria and established laboratory models to trace how these transport systems work and how they interact with the bacterial energy-transduction machinery. The goal is to identify bacterial mechanisms that could be targeted to prevent or better treat H. pylori infections.
Who could benefit from this research
Good fit: Ideal participants would be people with confirmed H. pylori infection, a history of peptic ulcer disease, or those willing to provide clinical samples for research.
Not a fit: People without H. pylori infection or whose stomach symptoms are due to unrelated conditions (for example, GERD not caused by H. pylori) are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could point to new targets for antibiotics or vaccines that more effectively clear H. pylori and lower ulcer and stomach cancer risk.
How similar studies have performed: Previous research has shown metal-uptake systems are important for H. pylori survival, but the specific TonB-dependent transporters studied here are novel and less well tested.
Where this research is happening
NASHVILLE, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COVER, TIMOTHY L — VETERANS HEALTH ADMINISTRATION
- Study coordinator: COVER, TIMOTHY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.