Exploring heart health in postmenopausal women
PGC-1, Purines and the Postmenopausal Heart
This study looks at how changes in estrogen levels may affect heart health in postmenopausal women and could lead to heart failure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 30 Years to 88 Years |
| Sex | All |
| Sponsor | Beth Israel Deaconess Medical Center Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT06015776 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of purinergic signaling in diastolic heart failure among postmenopausal women. It focuses on how estrogen deficiency affects cardiac remodeling and mitochondrial metabolism, potentially leading to heart failure with preserved ejection fraction (HFpEF). Researchers will analyze cardiac tissue from patients undergoing cardiac surgery to understand the molecular pathways involved. The study aims to clarify the relationship between estrogen, purinergic signaling, and cardiovascular health in aging women.
Who should consider this trial
Good fit: Ideal candidates are postmenopausal women undergoing cardiac surgery.
Not a fit: Patients with pre-existing heart conditions or those on hormone replacement therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of heart failure in postmenopausal women.
How similar studies have performed: Previous studies have indicated the importance of estrogen in cardiovascular health, suggesting potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing cardiac surgery under cardiopulmonary bypass. Exclusion Criteria: * Refusal to participate * Emergency surgery * Pre-existing heart block * Preexisting atrial fibrillation * Redo surgery * Estrogen or hormone replacement therapy * History of chronic heart failure * History of major kidney disease
Where this trial is running
Boston, Massachusetts
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Robina Matyal, MD — Beth Israel Deaconess Medical Center, Professor of Anesthesia
- Study coordinator: Robina Matyal, MD
- Email: rmatyal1@bidmc.harvard.edu
- Phone: 6176401208
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.