Evaluating exercise testing for diagnosing heart issues in patients with exertional dyspnea
A Retrospective and Prospective Cohort Study to Investigate the Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
This study is testing a new way to diagnose heart problems in people who get short of breath during exercise by using special tests that look at how the heart and lungs work together.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Samsung Medical Center Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT05490901 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the effectiveness of exercise hemodynamic testing combined with echocardiography in diagnosing patients who experience shortness of breath during physical activity. It focuses on individuals with heart failure with preserved ejection fraction (HFpEF) and chronic pulmonary thromboembolism, conditions that are often difficult to diagnose through standard resting tests. By comparing noninvasive testing methods with invasive measures of cardiovascular hemodynamics, the study seeks to enhance the understanding of cardiopulmonary mechanics during exercise. The goal is to establish a comprehensive diagnostic approach for evaluating exercise intolerance in these patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 19 and older who experience dyspnea on exertion.
Not a fit: Patients with advanced tumor disease, uncontrolled hypertension, or significant pulmonary limitations may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy for patients suffering from heart failure and related conditions, ultimately guiding better treatment strategies.
How similar studies have performed: While the approach of using exercise testing in this context is gaining attention, the specific combination of methods in this study is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject must be at least 19 years of age. * Patients with dyspnea on exertion * Written informed consent of participating subjects after being fully briefed (for prospective analysis) Exclusion Criteria: * Patients with incomplete hemodynamic data at rest or exercise * Advanced tumor disease or other diseases with a short life expectancy * Uncontrolled systemic arterial hypertension ( \> 160/100 mmHg at rest) * FEV1\<50% predicted * TLC\<60% predicted
Where this trial is running
Seoul
- Samsung Medical Center — Seoul, South Korea (Recruiting)
Study contacts
- Principal investigator: Jeong Hoon Yang, MD — Samsung Medical Center
- Study coordinator: Jeong Hoon Yang, MD
- Email: jhysmc@gmail.com
- Phone: 82-2-3410-3419
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.