Evaluating exercise testing for diagnosing heart issues in patients with exertional dyspnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the effectiveness of exercise hemodynamic testing combined with echocardiography in diagnosing patients who experience shortness of breath during physical activity. It focuses on individuals with heart failure with preserved ejection fraction (HFpEF) and chronic pulmonary thromboembolism, conditions that are often difficult to diagnose through standard resting tests. By comparing noninvasive testing methods with invasive measures of cardiovascular hemodynamics, the study seeks to enhance the understanding of cardiopulmonary mechanics during exercise. The goal is to establish a comprehensive diagnostic approach for evaluating exercise intolerance in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subject must be at least 19 years of age.
* Patients with dyspnea on exertion
* Written informed consent of participating subjects after being fully briefed (for prospective analysis)

Exclusion Criteria:

* Patients with incomplete hemodynamic data at rest or exercise
* Advanced tumor disease or other diseases with a short life expectancy
* Uncontrolled systemic arterial hypertension ( \> 160/100 mmHg at rest)
* FEV1\<50% predicted
* TLC\<60% predicted

Where it's running

• Samsung Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Jeong Hoon Yang, MD — Samsung Medical Center
• Study coordinator: Jeong Hoon Yang, MD
• Email: jhysmc@gmail.com
• Phone: 82-2-3410-3419

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Remote rehabilitation for HFpEF patients using telerehabilitation

  A home-based telerehabilitation program is being tested to see if it is safe and helpful for people with heart failure with preserved ejection fraction.

  Recruiting at 3 sites American Heart of Poland · Chrzanów and 2 other locations · NCT07918209

• EDG-15400 in adults with HFpEF: a phase 2 study

  This phase 2 study tests different doses of EDG-15400 against placebo in adults with HFpEF to see if it is safe and tolerable.

  Recruiting at 4 sites Phase 2 Edgewise Therapeutics, Inc. · Birmingham, Alabama and 27 other locations · NCT07795814

• Incretin therapy with tirzepatide for obesity-related HFpEF

  A 15-month study will test whether tirzepatide helps people with obesity and HFpEF by reducing plasma volume.

  Recruiting Phase 4 Columbia University · New York, New York · NCT07554638

• Boosted exercise with group coaching for HFpEF

  This trial tests a blended, guided exercise program with group coaching and remote monitoring to see if it helps older adults with HFpEF improve activity and health at a lower cost.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT07413198

• Exercise cardiac MRI for heart failure with preserved ejection fraction

  This study will try low-field exercise cardiac MRI to see if it can diagnose, describe, and predict risk in people with HFpEF compared with those who have non-cardiac breathlessness and healthy volunteers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07401771

• HRS-1893 for heart failure with preserved ejection fraction

  This trial will test whether HRS-1893 is safe and tolerable in adults aged 40 and older who have heart failure with preserved ejection fraction.

  Recruiting Phase 2 Shandong Suncadia Medicine Co., Ltd. · Shanghai, Shanghai Municipality · NCT07269717

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.