Condition

Heart Failure, Diastolic clinical trials and research

• 12Clinical trials
• 9Countries

Newest Heart Failure, Diastolic clinical trials

All recruiting trials (12)

• Incretin therapy with tirzepatide for obesity-related HFpEF

  A 15-month study will test whether tirzepatide helps people with obesity and HFpEF by reducing plasma volume.

  Recruiting Phase 4 Columbia University · New York, New York · NCT07554638

• LY3971297 in heart failure: safety and tolerability in HF with preserved and reduced ejection fraction

  This study tests how well LY3971297 is tolerated and what side effects occur in people with HFpEF or HFrEF.

  Recruiting Phase 1 Eli Lilly and Company · Detroit, Michigan and 11 other locations · NCT07547540

• Acetazolamide versus metolazone added to usual diuretics for acute decompensated heart failure

  This trial will test whether adding acetazolamide or metolazone to standard diuretics works better and is safer for adults hospitalized with acute decompensated heart failure.

  Recruiting University of Health Sciences Lahore · Chak Eighty-seven -Twelve Left, Punjab Province · NCT07199088

• Gene therapy for heart failure with preserved ejection fraction

  This study is testing a new gene therapy to see if it can help people with heart failure feel better by improving how their heart relaxes and fills with blood.

  Recruiting Phase 1 Sardocor Corp. · Durham, North Carolina and 1 other locations · NCT06061549

• Exploring the links between oral bacteria, muscle blood flow, and fitness levels

  This study is trying to see how oral bacteria and fitness levels affect blood flow to muscles in people.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06009276

• Comparing Aortix Device to Diuretics for Acute Heart Failure

  This study is testing whether the Aortix device can help people with acute heart failure who aren't responding to diuretics feel better compared to standard treatment.

  Recruiting at 33 sites Procyrion · Phoenix, Arizona and 49 other locations · NCT05677100

• Optimizing beta-blocker use in older adults with heart failure

  This study is trying to see if a personalized approach to adjusting beta-blocker medication can help older adults with heart failure feel more confident in their treatment and manage their condition better.

  Recruiting Phase 4 Weill Medical College of Cornell University · New York, New York · NCT05585125

• Evaluating the prevalence of transthyretin amyloidosis in heart failure patients

  This study is trying to find out how common transthyretin amyloidosis is in older heart failure patients to help catch it early for better treatment.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05577819

• Assessing risk factors in heart failure with preserved ejection fraction

  This study is trying to find out what factors can predict hospital visits and death in people with heart failure who still have a good heart function.

  Recruiting University Medical Center Groningen · Groningen · NCT05479669

• Investigating heart disease risk factors in psoriasis patients

  This study is trying to see if certain heart-related markers can help predict heart disease risk in people with psoriasis.

  Recruiting Herlev and Gentofte Hospital · Hellerup, Copenhagne · NCT04950218

• Using advanced imaging techniques to improve diagnosis and understanding of heart failure with preserved ejection fraction

  This study is trying to see if advanced imaging techniques can help doctors better diagnose and understand heart failure with preserved ejection fraction so they can help patients sooner.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality · NCT04603404

• Evaluating heart failure with preserved ejection fraction using advanced imaging techniques

  This study is trying to see if advanced imaging techniques can help doctors better understand and diagnose heart failure with preserved ejection fraction in patients.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality · NCT04602338

Related topics

Quick answers

How many Heart Failure, Diastolic clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (7 trials), Netherlands (2 trials), China (2 trials), Denmark (1 trial), Hungary (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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