Condition

Heart Failure With Reduced Ejection Fraction clinical trials and research

• 44Clinical trials
• 27Countries

Newest Heart Failure With Reduced Ejection Fraction clinical trials

All recruiting trials (44)

• Yoga-based cardiac rehabilitation for heart failure with reduced ejection fraction

  This trial tests whether a yoga-based rehabilitation program can help people with heart failure and reduced ejection fraction compared with an educational program.

  Recruiting at 12 sites Centre for Chronic Disease Control, India · Dharwad, Karnataka and 15 other locations · NCT07817589

• Lumacaftor to improve cerebral blood flow in heart failure with reduced ejection fraction

  This study tests whether lumacaftor can improve brain blood flow and thinking abilities in adults with a certain type of heart failure.

  Recruiting Phase 2 Qanatpharma AG · Toronto, Ontario and 1 other locations · NCT07695090

• Stepwise withdrawal of ARNI and SGLT2i in HF with normalized ejection fraction

  This trial tests whether gradually stopping ARNI and SGLT2i is safe for people whose heart function has recovered after fixing a reversible heart‑disease cause.

  Recruiting Phase 4 Keimyung University Dongsan Medical Center · Daegu, Daegu and 4 other locations · NCT07631156

• Ring-style blood pressure bracelet test compared with 24-hour monitoring in people with HFrEF

  A ring-type blood pressure device is being tested to see if its 24-hour readings match those from standard ambulatory monitoring in adults with heart failure and reduced ejection fraction.

  Recruiting Keimyung University Dongsan Medical Center · Daegu · NCT07626879

• Diet and exercise plan to help people with heart failure and preserved heart function.

  This study tests whether a DASH-style, high-protein diet, resistance exercise, or both can help build muscle and improve fitness and quality of life in people with heart failure and reduced ejection fraction.

  Recruiting Medical University of Silesia · Zabrze, Silesian Voivodeship · NCT07595809

• HFrEF polypill strategy in Sri Lanka

  This study tests whether giving a heart failure polypill can reduce death from heart disease and hospitalizations in adults with HFrEF in Sri Lanka, compared with usual care.

  Recruiting at 10 sites Phase 3 Washington University School of Medicine · Kandy, Central Province and 11 other locations · NCT07569640

• How metoprolol works in HFrEF patients with low versus high beta‑blocker genetic scores

  This trial will test if people with HFrEF who have a high beta‑blocker polygenic score respond differently to metoprolol than those with a low score.

  Recruiting Phase 4 University of Michigan · Ann Arbor, Michigan · NCT07490067

• HJB647 safety and tolerability in people with heart failure and reduced ejection fraction.

  This trial will test two doses of the experimental drug HJB647 versus placebo to see if it's safe and tolerated in adults with stable heart failure and reduced or mildly reduced ejection fraction who are already on sacubitril/valsartan.

  Recruiting at 6 sites Phase 1 Novartis · Bradenton, Florida and 5 other locations · NCT07465653

• Digital remote care to optimize heart-failure medicines after hospital discharge

  This trial will test whether a digital remote-management program helps adults recently hospitalized with HFrEF get their heart-failure medicines to recommended doses and avoid bad outcomes.

  Recruiting at 4 sites Beijing Anzhen Hospital · Beijing and 5 other locations · NCT07352891

• Digital support program for people with reduced ejection fraction heart failure

  This study will test a digital support program to help adults with reduced ejection fraction heart failure manage their condition and feel more in control.

  Recruiting Linkoeping University · Linköping, Östergötland County · NCT07275931

• Pulmonary Artery Denervation for a specific type of heart and lung pressure problem

  This study tests whether the Enhancor System can safely and effectively help patients with combined pre- and post-capillary pulmonary hypertension due to left heart disease when added to standard therapy.

  Recruiting at 18 sites Pulnovo Medical, Inc. · Tucson, Arizona and 18 other locations · NCT07214376

• Digital stethoscope and 3-lead ECG detection of pulmonary hypertension and low ejection fraction

  This project will test whether heart sounds and a three-lead ECG recorded with a digital stethoscope can find pulmonary hypertension or low left ventricular ejection fraction in adults having an echocardiogram.

  Recruiting at 4 sites Eko Devices, Inc. · O'Fallon, Illinois and 3 other locations · NCT07087613

• Inspiratory muscle training combined with cardiac rehabilitation for heart failure with reduced ejection fraction

  This trial will try inspiratory muscle training added to cardiac rehabilitation to see if it improves heart function and exercise responses in adults with heart failure and reduced ejection fraction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07086131

• Telemedicine-guided GDMT optimization for heart failure (DIGNITY)

  This program will test whether telemedicine-guided care can help hospitalized patients with reduced ejection fraction get to guideline-recommended heart-failure medications and doses faster than usual care after discharge in Switzerland.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT06942221

• Remote monitoring with Caaring for people with reduced ejection fraction heart failure

  Test whether using the Caaring smartphone app for remote monitoring helps people with reduced ejection fraction heart failure avoid hospital readmission over 12 weeks.

  Recruiting Persei Vivarium · Ferrol, A Coruña and 1 other locations · NCT06920160

• Evaluation of the Vsling™ Device for Heart Failure Treatment

  This study is testing a new device called Vsling™ to see if it can help people with heart failure feel better by repairing their heart's function.

  Recruiting at 2 sites Phase 2 Cardiac Success · Be’er Ya‘aqov and 4 other locations · NCT06851949

• Gene therapy to improve heart function in heart failure patients

  This study is testing a new gene therapy called YAP101 to see if it can help improve heart function in adults with heart failure.

  Recruiting Phase 1 Medley Therapeutics · Houston, Texas · NCT06831825

• Eccentric exercise program for older adults with heart failure and muscle loss

  This study is testing a 12-week exercise program for older adults with heart failure and muscle loss to see if it can help them get stronger and feel better.

  Recruiting at 2 sites Universita di Verona · Verona, Verona and 1 other locations · NCT06826963

• Using Apple Watch data to predict heart failure outcomes

  This study is testing if data from Apple Watches can help predict heart failure problems and the chances of needing to go back to the hospital for patients with heart failure.

  Recruiting University Medical Center Goettingen · Goettigen, Lower Saxony · NCT06819618

• High-fat diet for heart metabolism in non-ischemic dilated cardiomyopathy

  A small human study will test whether a high-fat diet can improve heart function in adults with non-ischemic dilated cardiomyopathy and reduced ejection fraction.

  Recruiting at 3 sites Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III · Paris and 4 other locations · NCT06747429

• Using omecamtiv mecarbil to treat chronic heart failure with severely reduced ejection fraction

  This study is testing if a new drug called omecamtiv mecarbil can help people with severe chronic heart failure live longer and avoid serious heart problems.

  Recruiting at 205 sites Phase 3 Cytokinetics · Alexander City, Alabama and 212 other locations · NCT06736574

• Synchronized diaphragmatic stimulation for symptomatic heart failure

  This study will test whether a small implanted device that delivers timed diaphragmatic stimulation can help people with heart failure with reduced ejection fraction (LVEF ≤40%) who remain symptomatic on guideline medical therapy.

  Recruiting at 5 sites VisCardia Inc. · Indianapolis, Indiana and 4 other locations · NCT06552637

• Improving heart failure treatment through clinician and patient tools

  This study is testing new tools for doctors and patients to see if they can help improve heart failure treatment for people with reduced heart function.

  Recruiting at 5 sites University of Colorado, Denver · Walnut Creek, California and 4 other locations · NCT06526988

• Observational study of heart failure patients in Vietnam

  This study is looking to gather information about heart failure patients in Vietnam to see how they are doing after leaving the hospital and how different treatments affect their health over time.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City · NCT06516562

• Diet-management app and smart scale for weight loss in people with heart failure and obesity

  This tests whether using a diet-management phone app at each meal plus a smart weight scale daily for 12 months helps people with heart failure and obesity live longer, avoid hospital stays, and feel less frail.

  Recruiting at 19 sites Heart Health Research Center · Beijing, Beijing Municipality and 25 other locations · NCT06455878

• Impact of weight loss on heart function in obese patients with heart failure

  This study is testing if losing weight with the help of a medication and a special diet can improve heart function and quality of life for obese patients with heart failure.

  Recruiting Phase 2/3 Hvidovre University Hospital · Copenhagen · NCT06423599

• Midodrine in heart failure with reduced ejection fraction and low blood pressure

  This study tests whether adding midodrine helps patients with HFrEF and hypotension when standard heart failure therapy is limited by low blood pressure.

  Recruiting Phase 2/3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06405555

• Breathing-linked pacemaker pacing after bypass surgery for heart failure with reduced ejection fraction

  This will test a pacemaker setting that restores the heart's natural breathing-linked rate in people with reduced ejection fraction after bypass surgery to see if it is safe and improves heart function.

  Recruiting at 3 sites Ceryx Medical Ltd · Adelaide, South Australia and 2 other locations · NCT06384963

• Assessing heart function in patients with right heart failure

  This study is trying to find better ways to spot and treat right heart problems in people with heart failure and high blood pressure in the lungs by looking at how their heart functions during exercise.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06299436

• Using colchicine to treat acutely decompensated heart failure with reduced ejection fraction

  This study is testing if colchicine, an anti-inflammatory medication, can help people in the hospital with heart failure feel better and improve their heart function.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT06286423

• Improving exercise capacity in heart failure patients using conduction system pacing

  This study is testing if a new type of heart pacing can help people with heart failure exercise better than the standard pacing method.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06278844

• Using empagliflozin to treat heart failure in patients with end stage renal disease

  This study is testing if empagliflozin can help people with heart failure who are on dialysis feel better and improve their heart function.

  Recruiting at 2 sites Phase 4 National Taiwan University Hospital · Hsinchu, Taiwan and 1 other locations · NCT06249932

• Monitoring heart function with a wireless sensor for heart failure patients

  This study tests whether a wireless sensor can help doctors keep a closer eye on heart function in patients with heart failure and mitral regurgitation to improve their treatment and outcomes.

  Recruiting Columbia University · New York, New York · NCT06241430

• SGLT2 medication and ketone effects on heart function in people with type 2 diabetes and reduced ejection fraction

  This will test whether taking empagliflozin, which raises blood ketones, helps the heart pump and fill better in adults with type 2 diabetes and heart failure with reduced ejection fraction.

  Recruiting Early Phase 1 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT06229678

• Weaning heart failure treatment for patients recovering from tachycardia-induced cardiomyopathy

  This study is testing if slowly reducing heart failure medications is just as effective as keeping patients on full treatment after they’ve recovered from tachycardia-induced cardiomyopathy.

  Recruiting Phase 2/3 Herlev and Gentofte Hospital · Copenhagen · NCT06128980

• Using a pulmonary artery catheter and early carvedilol treatment for cardiogenic shock in heart failure patients

  This study is testing if using a special heart monitor along with early treatment with carvedilol can help heart failure patients in cardiogenic shock live longer and need less medication.

  Recruiting Asan Medical Center · Seoul · NCT06078436

• Effects of Ferric Derisomaltose on Exercise Capacity and Quality of Life in Heart Failure Patients

  This study is testing if adding Ferric Derisomaltose to regular treatment can help people with heart failure and low iron feel better and exercise more easily.

  Recruiting Phase 4 China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT05971732

• Effects of weight loss on heart function in obese patients with heart failure

  This study tests if losing weight can help people with heart failure feel better and improve their heart function.

  Recruiting at 2 sites University of Oxford · Jersey, Jersey and 1 other locations · NCT05942287

• Comparing revascularization and medical treatment for heart failure with reduced ejection fraction

  This study is testing if opening blocked arteries with a procedure helps people with heart failure feel better compared to just taking medication.

  Recruiting Samsung Medical Center · Seoul · NCT05828719

• Comparing His and Left Bundle Branch Pacing for Heart Failure

  This study is testing whether a new way of pacing the heart can help people with heart failure feel better and stay out of the hospital compared to the usual treatment.

  Recruiting at 62 sites Baylor College of Medicine · Gilbert, Arizona and 70 other locations · NCT05650658

• New exercise program for older patients with heart failure

  This study is testing a new exercise program for older patients with heart failure to see if it helps them feel better compared to a standard exercise program.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05609097

• Improving heart failure treatment with advanced cardiac mapping

  This study is testing if using advanced heart mapping to guide a specific heart treatment can help people with heart failure feel better compared to the usual methods.

  Recruiting EP Solutions SA · Amsterdam and 10 other locations · NCT05564793

• Monitoring heart failure patients in real-time at Yale New Haven Health System

  This study is trying to see how real-time monitoring of heart failure patients at Yale New Haven Health System can help improve their care and treatment.

  Recruiting Yale University · New Haven, Connecticut · NCT04237701

• Registry for Patients With and Without Heart Failure

  This study is looking to understand different types of heart failure by gathering health information from people aged 18 and older, both with and without the condition, to improve treatment options.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT03480633

Related topics

Quick answers

How many Heart Failure With Reduced Ejection Fraction clinical trials are recruiting right now?

44, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (17 trials), China (5 trials), Canada (5 trials), South Korea (4 trials), Italy (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 5, Phase 2/3: 3, Phase 3: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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