Testing methods for diagnosing heart failure with preserved ejection fraction
Provocative Tests for Diagnosing and Phenotyping Heart Failure With Preserved Ejection Fraction
Istituto Auxologico Italiano · NCT06309550
This study is testing new ways to diagnose heart failure with preserved ejection fraction in people who have trouble breathing during exercise to see if they can improve current methods.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Sex | All |
| Sponsor | Istituto Auxologico Italiano (other) |
| Locations | 1 site (Milan) |
| Trial ID | NCT06309550 on ClinicalTrials.gov |
What this trial studies
This observational study aims to improve the diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients experiencing exertional breathlessness. It evaluates the effectiveness of exercise right heart catheterization and invasive cardiopulmonary exercise testing as gold-standard diagnostic methods, while also exploring the potential of non-invasive tests and other provocative tests. The study seeks to address the challenges posed by low sensitivity of current diagnostic algorithms and the impact of comorbidities on symptom interpretation. By comparing results from different cohorts, the study aims to enhance diagnostic accuracy for HFpEF.
Who should consider this trial
Good fit: Ideal candidates for this study are patients experiencing dyspnea without a known diagnosis of HFpEF.
Not a fit: Patients who already have a confirmed diagnosis of HFpEF will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of HFpEF, improving patient management and outcomes.
How similar studies have performed: While some studies have explored similar diagnostic approaches, this study aims to provide new insights specific to Italian cohorts, making it a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * dyspnea Exclusion Criteria: * known HFpEF
Where this trial is running
Milan
- Ospedale San Luca IRCCS Istituto Auxologico Italiano — Milan, Italy (RECRUITING)
Study contacts
- Study coordinator: Sergio Caravita, MD, PhD
- Email: s.caravita@auxologico.it
- Phone: +39 02 619112930
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Heart Failure With Preserved Ejection Fraction