Testing methods for diagnosing heart failure with preserved ejection fraction
Official title: Provocative Tests for Diagnosing and Phenotyping Heart Failure With Preserved Ejection Fraction
Run by Istituto Auxologico Italiano · NCT06309550 · Data updated 2026-11-12
This study is testing new ways to diagnose heart failure with preserved ejection fraction in people who have trouble breathing during exercise to see if they can improve current methods.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Istituto Auxologico Italiano Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | March 10, 2023 |
| Main results expected | March 2028 |
| Study ends | March 2028 |
| Registry record updated | August 3, 2025 |
| Trial ID | NCT06309550 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients experiencing dyspnea without a known diagnosis of HFpEF.
✕Probably not a fit
Patients who already have a confirmed diagnosis of HFpEF will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to improve the diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients experiencing exertional breathlessness. It evaluates the effectiveness of exercise right heart catheterization and invasive cardiopulmonary exercise testing as gold-standard diagnostic methods, while also exploring the potential of non-invasive tests and other provocative tests. The study seeks to address the challenges posed by low sensitivity of current diagnostic algorithms and the impact of comorbidities on symptom interpretation. By comparing results from different cohorts, the study aims to enhance diagnostic accuracy for HFpEF.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of HFpEF, improving patient management and outcomes.
How similar studies have gone: While some studies have explored similar diagnostic approaches, this study aims to provide new insights specific to Italian cohorts, making it a novel investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * dyspnea Exclusion Criteria: * known HFpEF
Where it's running
-
Ospedale San Luca IRCCS Istituto Auxologico Italiano
Milan, Italy Recruiting
Study contacts
- Study coordinator: Sergio Caravita, MD, PhD
- Email: s.caravita@auxologico.it
- Phone: +39 02 619112930
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Remote rehabilitation for HFpEF patients using telerehabilitation
A home-based telerehabilitation program is being tested to see if it is safe and helpful for people with heart failure with preserved ejection fraction.
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EDG-15400 in adults with HFpEF: a phase 2 study
This phase 2 study tests different doses of EDG-15400 against placebo in adults with HFpEF to see if it is safe and tolerable.
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Incretin therapy with tirzepatide for obesity-related HFpEF
A 15-month study will test whether tirzepatide helps people with obesity and HFpEF by reducing plasma volume.
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Boosted exercise with group coaching for HFpEF
This trial tests a blended, guided exercise program with group coaching and remote monitoring to see if it helps older adults with HFpEF improve activity and health at a lower cost.
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Exercise cardiac MRI for heart failure with preserved ejection fraction
This study will try low-field exercise cardiac MRI to see if it can diagnose, describe, and predict risk in people with HFpEF compared with those who have non-cardiac breathlessness and healthy volunteers.
-
HRS-1893 for heart failure with preserved ejection fraction
This trial will test whether HRS-1893 is safe and tolerable in adults aged 40 and older who have heart failure with preserved ejection fraction.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.