Condition

Brain Metastasis clinical trials and research

• 13Clinical trials
• 63NIH research projects
• 1New in 30 days
• 8Countries

Newest Brain Metastasis clinical trials

All recruiting trials (13)

• ePRO in advanced lung cancer: emotional distress, brain metastasis, and symptom burden

  This study tests how patients with advanced lung cancer—some with brain metastases—report emotional distress and symptoms over time using electronic questionnaires.

  Recruiting Tongji Hospital · Hubei, Wuhan · NCT07912190

• What causes vulnerability in older adults with serious diseases and how it affects care decisions

  This study tests how often vulnerability factors appear in older adults with serious illnesses and how these factors influence treatment timing, survival, and quality of life.

  Recruiting Tampere University Hospital · Tampere · NCT07740239

• Omitting brain metastasis radiation after tumor removal when CNS-active therapy is used

  This pilot study tests whether patients with resected brain metastases from melanoma or NSCLC can skip post-operative brain radiation while receiving CNS-active systemic therapy.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT07655583

• Sac-TMT plus bevacizumab in TNBC with brain metastases

  This phase II, single-arm study tests whether Sac-TMT combined with bevacizumab can help people with triple-negative breast cancer and brain metastases.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07623577

• Combined intracranial and intravenous NK cell therapy for malignant brain tumors

  This trial will test whether giving adults with recurrent malignant brain tumors their own expanded and activated natural killer (NK) cells into the tumor site and into the bloodstream is safe and feasible.

  Recruiting at 3 sites Peking University Third Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07552233

• Cognitive stepped care program for adults with brain metastases

  This project will test whether routine screening plus a stepped program of education and tailored cognitive support can help adults with brain metastases manage thinking and memory problems.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07355348

• Intraoperative neuronal recordings during brain tumor surgery

  This study tries out a Neuropixel probe to record brain activity during awake tumor removal in adults with glioma or brain metastases to explore how neurons interact with tumors.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT06617208

• MRI-guided radiotherapy for lung cancer with brain metastasis

  This study is testing whether a new type of MRI-guided radiotherapy without extra safety margins can be as effective and safe as the traditional CT-guided radiotherapy for patients with lung cancer that has spread to the brain.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT06582940

• Understanding how breast cancer spreads to the brain

  This study is trying to understand how breast cancer spreads to the brain in patients who have had surgery for brain tumors, to help find better treatments.

  Recruiting Samsung Medical Center · Seoul · NCT06330870

• New imaging methods for detecting brain tumors in patients with metastasis

  This study is testing new imaging techniques to see if they can better detect brain tumors in patients who have cancer that has spread to the brain.

  Recruiting Phase 3 University of Wisconsin, Madison · Madison, Wisconsin · NCT06159335

• Hypofractionated (3×10 Gy) versus single‑dose (20–25 Gy) stereotactic radiotherapy for limited brain metastases

  This trial will try whether giving stereotactic radiotherapy in three 10 Gy sessions works as well or better than the traditional single high‑dose (20–25 Gy) radiosurgery for adults with up to five small brain metastases.

  Recruiting at 6 sites Centre Francois Baclesse · Bordeaux and 14 other locations · NCT05102747

• Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Cognitive Function

  This study is testing whether a special type of brain radiation that avoids the hippocampus can help people with brain tumors keep their thinking skills better than regular radiation.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT02504788

• Hippocampal-sparing radiation for lung cancer patients

  This study tests a new type of radiation therapy for lung cancer patients to see if it can prevent brain cancer while protecting their memory.

  Recruiting Phase 2/3 Chang Gung Memorial Hospital · Taoyuan · NCT02448992

NIH-funded research (newest 40 of 63)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Nanoparticles that boost MRI to find tiny brain metastases

  This uses tiny magnetic nanoparticles and new MRI image processing to help doctors find very small brain metastases earlier in people with cancer.

  NIH research University of California at Davis · Davis, United States · NIH-11467320

• Prolactin signaling and brain metastasis in HER2-positive breast cancer

  Researchers are studying how prolactin signals help HER2-positive breast cancer cells grow in the brain, with the goal of finding new ideas to prevent brain metastases.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11434654

• ATM kinase as a target to help NSCLC with brain metastases respond to treatment

  A study from Yale University tests whether blocking ATM kinase can delay or overcome treatment resistance in people with advanced non-small cell lung cancer that has spread to the brain and other organs.

  NIH research Yale University · New Haven, United States · NIH-11417454

• How an immune signal in brain support cells helps breast cancer spread to the brain

  This project looks at whether a specific immune signal in brain support cells (astrocytes) helps breast cancer cells grow in the brain, aiming to help people with breast cancer that has spread to the brain.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11415817

• Brain cancer cells and brain cells talk to each other to spread to the brain

  A research project uses computer and mouse studies to understand how cancer cells that spread from breast or lung tumors grow in the brain and interact with brain support cells.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11415150

• How brain support cells' recycling affects breast cancer spread to the brain

  This project looks at whether blocking a cell-recycling process in brain support cells can prevent or slow breast cancer that spreads to the brain in people with breast cancer.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11409057

• Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis

  A study testing a virus-based cancer therapy to help treat breast cancer that has spread to the brain, with focus on boosting the body’s immune response to fight the tumors.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11402019

• Brain metastasis targeting and therapy in small cell lung cancer

  A new plan to study why small cell lung cancer spreads to the brain and how to treat those brain metastases with safer, more effective options.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11391984

• Understanding brain-metastasis CD8+ T cells and how they fight cancer in the brain

  This grant studies how a special type of immune cells, CD8+ T cells, behaves inside brain tumors to find ways to improve immune-based cancer therapies.

  NIH research Emory University · Atlanta, United States · NIH-11391292

• NRG3 and breast cancer brain metastasis: what drives spread to the brain and how to stop it

  This grant explores how the NRG3 protein helps breast cancer cells spread to the brain and whether this knowledge can lead to new treatments.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11366698

• Exploring how MHC-II and Lag3 in the brain could stop breast cancer from spreading there

  A study is looking at how the immune signals in the brain interact with breast cancer cells that have spread to the brain, to find new ways to treat this serious problem.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11361152

• A shortened GLI1 protein and tiny RNA signals linked to breast cancer spread to the brain

  This project looks at whether a shortened form of the GLI1 protein and certain microRNAs help breast cancer cells move to and grow in the brain.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11358118

• Regulatory T cells and astrocyte changes in brain metastasis

  This project studies how immune cells called regulatory T cells interact with brain-supporting cells to influence brain metastasis in cancer patients.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11345285

• Fibroblasts in brain metastases help cancer grow and hide from treatment

  In people with cancer that has spread to the brain, researchers are studying how lung cancer–driven fibroblasts in the brain help cancer cells grow, resist standard therapies, and dampen the immune response.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11345207

• Breast cancer brain mets: guiding CAR T therapy with focused ultrasound

  A new approach uses focused ultrasound guided by MRI to help CAR T cells target HER2-positive breast cancer that has spread to the brain.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11329071

• Immune treatment for melanoma that has spread to the brain

  Seeing whether adding the blood-vessel drug bevacizumab to the immune drug pembrolizumab helps people with melanoma that has spread to the brain work better than immune therapy alone.

  NIH research Yale University · New Haven, United States · NIH-11303348

• Mapping HER2 and blood flow in HER2-positive breast cancer that has spread to the brain

  Using advanced PET/MRI scans to map how HER2 protein and blood flow vary inside brain metastases in people with HER2-positive breast cancer before they get targeted drugs and radiation.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11291301

• Breast cancer protein that opens the brain's protective barrier

  Looking at whether a sugar-coated protein made by some breast tumors helps cancer cells get into the brain, to help people with advanced breast cancer who are at risk of brain metastases.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11291289

• Osimertinib resistance and brain metastasis in lung cancer

  This grant aims to create animal models of osimertinib resistance that spread to the brain in lung cancer, to help scientists understand why some patients stop responding and develop brain tumors.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11285092

• Breast cancer signals that drive spread to the brain

  This project looks at whether tiny RNA messages released by breast tumors change brain cells and appear in blood to help prevent or treat breast cancer that spreads to the brain.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11262265

• New treatment approaches for cancer that spreads to the brain

  This work looks at whether Alzheimer’s drugs that target amyloid-beta can help people whose melanoma, lung, or breast cancer has spread to the brain.

  NIH research New York University School of Medicine · New York, United States · NIH-11258531

• How loss of the AMPK energy sensor may help melanoma spread to the brain

  This project checks whether losing the AMPKα2 protein helps melanomas—especially NF1-mutant tumors—grow and spread to the brain.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11253302

• Nanoprobe-enhanced MRI to find tiny brain metastases

  A new MRI nanoprobe plus image-processing method to help doctors spot very small brain metastases earlier in people with cancer.

  NIH research University of California at Davis · Davis, United States · NIH-11231684

• Improving brain imaging to detect small tumors earlier

  This study is testing a new imaging method that uses special technology to help doctors find small brain tumors that are often overlooked, making it easier to diagnose and treat them early, so patients can get better care.

  NIH research University of California at Davis · Davis, United States · NIH-11221497

• Enhanced virus-based immunotherapy for breast cancer that has spread to the brain

  This project explores a modified herpes virus treatment designed to help the immune system fight breast cancer that has spread to the brain.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11210788

• Improving viral immunotherapy for breast cancer that has spread to the brain

  This project tries to improve a cancer-killing herpes virus plus immune therapy to help people with breast cancer that has spread to the brain.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11184335

• How cancer cells and brain support cells interact in brain metastases

  This project looks at how breast and lung cancer cells interact with brain cells to explain why some cancers spread to the brain and how to stop them.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11176066

• Improving immune treatments for cancers that have spread to the brain

  Researchers will try blocking a molecule called TGF-β in lymph nodes to help immune therapies work better for people whose cancer has spread to the brain.

  NIH research Stanford University · Stanford, United States · NIH-11174237

• Improving treatment for breast cancer that has spread to the brain

  This study is looking for ways to make a promising new treatment for breast cancer that has spread to the brain work better, by helping your immune system fight the cancer more effectively.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11131347

• Breast cancer's role in opening the blood-brain barrier and causing brain metastasis

  This study is looking at how certain breast cancer cells can get into the brain by opening a protective barrier, and it focuses on a protein called fetuin-A that might help with this process, all to find new ways to stop or treat brain metastases in people with breast cancer.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11128244

• Understanding how immune cells interact with brain tumors to find new treatments

  This project looks at how the brain's immune cells talk to breast cancer cells that have spread to the brain, hoping to find new ways to stop these tumors from growing.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11124843

• Using advanced imaging to understand HER2+ breast cancer spread to the brain

  This study is looking at how HER2-positive breast cancer spreads to the brain and how well it responds to treatment, using special imaging techniques to help doctors find the best ways to target therapy for patients before they start radiation.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11112842

• Using focused ultrasound to enhance CAR T cell therapy for breast cancer that has spread to the brain

  This study is exploring a new way to help people with HER2-positive breast cancer that has spread to the brain by using focused ultrasound to make CAR T cell therapy work better, aiming to improve treatment success while reducing side effects.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11110308

• Fibroblasts help cancer cells grow in the brain and resist treatment.

  This study is looking at how certain cells in the body, called fibroblasts, help lung cancer spread to the brain and may make it harder for treatments to work, with the goal of finding new ways to help patients with brain metastases feel better.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11088164

• How immune cells affect brain cancer spread

  This study is looking at how certain immune cells in the body, called regulatory T cells, affect the growth of cancer in the brain, and it aims to find new ways to help patients whose cancer has spread there.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11083689

• Targeting lipid metabolism to improve treatment for HER2+ breast cancer that has spread to the brain

  This study is looking at how to make treatments work better for people with HER2 positive breast cancer that has spread to the brain by finding ways to block the cancer cells' use of fats to grow, which could help existing therapies be more effective.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11079642

• Investigating how a specific protein influences breast cancer spread to the brain

  This study is looking at how a protein called tGLI1 helps breast cancer spread to the brain, and it’s for anyone interested in understanding more about how breast cancer can affect the brain and what might help stop it.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11075129

• Understanding how certain proteins influence brain cancer spread

  This study is looking at how certain proteins help triple-negative breast cancer spread to the brain, with the goal of finding new ways to treat this condition and improve outcomes for patients.

  NIH research Duke University · Durham, United States · NIH-11070241

• Investigating how radiation and inflammation affect brain tumor growth.

  This study looks at how brain tumors and the immune system work together, especially focusing on important brain cells, to see how radiation therapy affects them and how they respond to inflammation, with the goal of finding better treatment options for people with brain metastasis.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11069934

• Understanding how small cell lung cancer spreads to the brain

  This study is looking into how small cell lung cancer spreads to the brain, which can be a tough challenge for patients, and it hopes to find new ways to treat this issue by understanding how the cancer cells behave in the brain.

  NIH research Stanford University · Stanford, United States · NIH-11065852

Related topics

Quick answers

How many Brain Metastasis clinical trials are recruiting right now?

13, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in China (4 trials), United States (2 trials), Taiwan (2 trials), Canada (1 trial), Finland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 1, Phase 3: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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