Condition

Newly Diagnosed Glioblastoma clinical trials and research

• 8Clinical trials
• 5Countries

Newest Newly Diagnosed Glioblastoma clinical trials

All recruiting trials (8)

• Maintenance radiotherapy after standard glioblastoma treatment

  This study tests whether a single 2 Gy maintenance radiotherapy dose after standard treatment is safe and feasible for adults with newly diagnosed glioblastoma.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07831772

• AAV dual-payload gene therapy injected directly into high-grade glioma to kill tumor cells and stimulate immune attack.

  This will try TGX-007, a virus-delivered gene therapy given into the tumor together with oral valaciclovir, in adults 18–70 with newly diagnosed or recurrent glioblastoma to see if it safely kills tumor cells and boosts immune response.

  Recruiting at 2 sites Phase 1/2 Trogenix ltd · Columbus, Ohio and 1 other locations · NCT07346144

• Silevertinib plus temozolomide for newly diagnosed GBM with unmethylated MGMT and EGFRvIII

  This trial tests whether adding silevertinib to standard temozolomide helps people with newly diagnosed glioblastoma that have EGFRvIII and an unmethylated MGMT promoter live longer without the cancer getting worse.

  Recruiting at 38 sites Phase 2 Black Diamond Therapeutics, Inc. · Birmingham, Alabama and 37 other locations · NCT07326566

• Anterior (front) temporal lobe removal for temporal glioblastoma

  This will see if removing the front part of the temporal lobe (anterior temporal lobectomy) helps people with newly diagnosed temporal-lobe glioblastoma live longer than standard complete tumor removal (gross-total resection).

  Recruiting Phase 3 University Hospital, Bonn · Bonn, North Rhine-Westphalia · NCT07021339

• Nivolumab with or without relatlimab for newly diagnosed IDH‑wildtype glioblastoma

  This trial will test whether giving nivolumab alone or together with relatlimab around surgery helps adults with newly diagnosed IDH‑wildtype glioblastoma.

  Recruiting at 4 sites Phase 2 Duke University · New York, New York and 3 other locations · NCT06816927

• New cancer vaccine for glioblastoma patients

  This study is testing a new cancer vaccine for people with newly diagnosed glioblastoma to see if it can help boost their immune response after standard treatment.

  Recruiting at 2 sites Phase 1/2 Assistance Publique - Hôpitaux de Paris · Paris, Idf and 2 other locations · NCT06622434

• Personalized drug screening for glioblastoma treatment

  This study is testing if personalized combinations of FDA-approved drugs can improve treatment for people with newly diagnosed glioblastoma when used with standard therapy.

  Recruiting Early Phase 1 Swedish Medical Center · Seattle, Washington · NCT05380349

• BRiTE: a brain-penetrant bispecific T cell engager for EGFRvIII-positive glioblastoma

  This Phase 1 study tests the safety of BRiTE, a brain-delivered bispecific T cell engager, in adults with newly diagnosed or recurrent EGFRvIII-positive glioblastoma.

  Recruiting Phase 1 Duke University · Durham, North Carolina · NCT04903795

Related topics

Quick answers

How many Newly Diagnosed Glioblastoma clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (6 trials), Australia (1 trial), Germany (1 trial), United Kingdom (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1/2: 2, Phase 1: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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