Condition

Glioblastoma Multiforme (GBM) clinical trials and research

• 11Clinical trials
• 5Countries

Newest Glioblastoma Multiforme (GBM) clinical trials

All recruiting trials (11)

• Imaging study of 203Pb-RMX-VH-PIB in GBM and PDAC patients

  This early-stage study tests a new imaging drug to see how it travels in the body and how much radiation different organs receive in adults with GBM or PDAC.

  Recruiting Phase 1 Radiomedix, Inc. · Houston, Texas · NCT07733674

• Combined intracranial and intravenous NK cell therapy for malignant brain tumors

  This trial will test whether giving adults with recurrent malignant brain tumors their own expanded and activated natural killer (NK) cells into the tumor site and into the bloodstream is safe and feasible.

  Recruiting at 3 sites Peking University Third Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07552233

• Paxalisib plus temozolomide for malignant brain tumours with PI3K pathway changes

  This trial tests whether adding paxalisib to standard temozolomide helps people with newly diagnosed MGMT-unmethylated glioblastoma whose tumors have PI3K-activating mutations or PTEN loss.

  Recruiting Phase 1/2 Institute of Cancer Research, United Kingdom · Sutton · NCT07391215

• Silevertinib plus temozolomide for newly diagnosed GBM with unmethylated MGMT and EGFRvIII

  This trial tests whether adding silevertinib to standard temozolomide helps people with newly diagnosed glioblastoma that have EGFRvIII and an unmethylated MGMT promoter live longer without the cancer getting worse.

  Recruiting at 38 sites Phase 2 Black Diamond Therapeutics, Inc. · Birmingham, Alabama and 37 other locations · NCT07326566

• Focused ultrasound to open the blood-brain barrier in adults with high-grade glioma on chemotherapy

  This trial tests whether focused ultrasound using the Next Generation Dome Helmet can safely open the blood-brain barrier in adults with glioblastoma who are receiving maintenance temozolomide chemotherapy.

  Recruiting Phase 1 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07179328

• Allogeneic γδ T cell therapy for glioblastoma

  This first-in-human trial will try locally delivered, genetically edited allogeneic γδ T cells (ABOUT γδT) to see if they are safe for adults with recurrent or progressive glioblastoma.

  Recruiting at 3 sites Peking University Third Hospital · Beijing, Beijing Municipality and 2 other locations · NCT07144735

• PSMA PET/CT for GBM patients on bevacizumab

  This study tests PSMA PET/CT scans in adults with IDH-wildtype glioblastoma who are receiving bevacizumab to see how PSMA expression relates to VEGF in their tumors.

  Recruiting Royal North Shore Hospital · Saint Leonards, New South Wales · NCT07052877

• Early‑phase KESONOTIDE™ treatment for solid tumors

  This trial tests an oral drug called KESONOTIDE™ (a vimentin inhibitor) to see if it is safe and tolerable in adults with advanced or metastatic solid tumors like prostate, breast, lung, ovarian cancer, or glioblastoma.

  Recruiting at 3 sites Phase 1/2 Filamon LTD · Kogarah, New South Wales and 2 other locations · NCT06926075

• Combination therapy for malignant brain tumors using avutometinib and defactinib

  This study is testing a new combination of two drugs, avutometinib and defactinib, to see if they can help people with advanced malignant brain tumors like glioblastoma feel better and improve their treatment options.

  Recruiting at 3 sites Phase 1/2 Institute of Cancer Research, United Kingdom · Cambridge and 2 other locations · NCT06630260

• Combining JK-1201I with Temozolomide for Newly Diagnosed Glioblastoma

  This study is testing if adding a new drug called JK-1201I to the standard treatment of temozolomide can help people who have just been diagnosed with glioblastoma feel better and live longer after their surgery.

  Recruiting Phase 2 JenKem Technology Co., Ltd. · Beijing · NCT06595186

• Combining capecitabine and temozolomide for newly diagnosed glioblastoma

  This study is testing if combining two cancer drugs, capecitabine and temozolomide, can help people with newly diagnosed glioblastoma live longer and feel better compared to using temozolomide alone.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT03213002

Related topics

Quick answers

How many Glioblastoma Multiforme (GBM) clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (3 trials), United States (3 trials), United Kingdom (2 trials), Australia (2 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 2: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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