Condition

Brain Metastasases clinical trials and research

• 9Clinical trials
• 5Countries

Newest Brain Metastasases clinical trials

All recruiting trials (9)

• SRS Before Surgery for Brain Metastases to Try Better Surgical Outcomes

  This study tests whether giving stereotactic radiosurgery to a single brain metastasis before its surgical removal can reduce cancer spread during surgery and improve recovery.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07802353

• Connectome-guided network planning for brain tumor surgery in eloquent areas

  This study tests whether using patient-specific brain network maps from diffusion MRI can help surgeons plan and guide brain tumor removal in eloquent areas.

  Recruiting ARNAS Civico Di Cristina Benfratelli Hospital · Palermo, PA · NCT07717827

• Radiotherapy with chemotherapy plus adebrelimab and bevacizumab for TNBC with brain metastases

  This phase II study tests a combination of radiotherapy, cisplatin or carboplatin, adebrelimab, and bevacizumab in adults with triple-negative breast cancer that has spread to the brain.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07638852

• Spinal fluid and blood liquid biopsy for people with metastatic solid tumors with or without brain involvement

  This will test whether a one-time spinal fluid (CSF) and blood sample can find tumor DNA in people with metastatic solid tumors, including those with brain metastases or leptomeningeal disease.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07476781

• B7-H3 targeted antibody-drug conjugate (risvutatug rezetecan) for recurrent Grade 4 glioma and brain metastases

  This study will try risvutatug rezetecan, a B7-H3 antibody-drug conjugate, in adults with recurrent Grade 4 glioma or brain metastases who are undergoing surgical resection.

  Recruiting Early Phase 1 St. Joseph's Hospital and Medical Center, Phoenix · Phoenix, Arizona · NCT07268053

• Combining Gamma Knife and Linac radiosurgery for large brain tumors and metastases

  This will test whether using both Gamma Knife and Linac stereotactic radiosurgery in adults with large brain tumors or brain metastases can improve tumor control and reduce side effects.

  Recruiting Phase 2 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07162246

• First-line bevacizumab versus dexamethasone for symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases.

  This trial will test whether first-line bevacizumab or dexamethasone works better at reducing symptoms in adults with symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases.

  Recruiting at 5 sites Phase 3 The Netherlands Cancer Institute · Amsterdam and 5 other locations · NCT06888817

• Using AI to predict treatment outcomes in lung cancer patients with brain metastases

  This study is testing if using artificial intelligence to look at brain and lung scans can help predict how well treatment will work for people with advanced lung cancer that has spread to the brain.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT06604689

• Combining alpelisib and pembrolizumab for advanced breast cancer and melanoma

  This study is testing a new combination treatment of alpelisib and pembrolizumab to see how safe it is for people with advanced melanoma and triple-negative breast cancer.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT06545682

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Quick answers

How many Brain Metastasases clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (3 trials), China (2 trials), Canada (2 trials), Netherlands (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 1, Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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