Condition

Astrocytoma, Grade IV clinical trials and research

• 6Clinical trials
• 10Countries

Newest Astrocytoma, Grade IV clinical trials

All recruiting trials (6)

• MR‑Linac guided adaptive 'dose‑painting' radiation with reduced margins for Grade 4 glioma

  This trial will test whether daily MRI‑guided adaptive 'dose‑painting' radiation with smaller treatment margins helps people with glioblastoma (Grade 4 astrocytoma) get better local tumor control and fewer side effects than standard radiation.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07459101

• Treatment of high-grade glioma in young patients using olutasidenib and temozolomide

  This study is testing if a new combination of olutasidenib and temozolomide can help young patients with high-grade gliomas that have a specific mutation feel better after their radiotherapy.

  Recruiting at 8 sites Phase 2 Rigel Pharmaceuticals · Aurora, Colorado and 19 other locations · NCT06161974

• Comparing two surgical approaches for high-grade glioma patients

  This study is testing whether a more extensive surgical method for removing high-grade brain tumors helps patients live longer and feel better compared to a standard approach.

  Recruiting at 6 sites Erasmus Medical Center · San Francisco, California and 7 other locations · NCT06118723

• Using fat-derived stem cells to treat recurrent brain tumors during surgery

  This study is testing whether injecting fat-derived stem cells directly into the brain during surgery can help people with recurrent brain tumors feel better and live longer.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT05789394

• Safusidenib as maintenance therapy for IDH1‑mutant astrocytoma and oligodendroglioma

  This trial tests whether the oral drug safusidenib can help people with IDH1‑mutant astrocytomas or oligodendrogliomas remain progression‑free longer after surgery and standard radiation/chemotherapy.

  Recruiting at 59 sites Phase 3 Nuvation Bio Inc. · Birmingham, Alabama and 60 other locations · NCT05303519

• Comparing awake craniotomy and general anesthesia for glioblastoma surgery

  This study is testing whether having brain surgery while awake is safer and more effective than having it under general anesthesia for people with glioblastoma in important areas of the brain.

  Recruiting at 5 sites Erasmus Medical Center · Ghent and 4 other locations · NCT03861299

Related topics

Quick answers

How many Astrocytoma, Grade IV clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (4 trials), Netherlands (3 trials), Canada (2 trials), Belgium (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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