Condition

Gastroesophageal Reflux clinical trials and research

• 15Clinical trials
• 6NIH research projects
• 9Countries

Newest Gastroesophageal Reflux clinical trials

All recruiting trials (15)

• POEM vs Heller myotomy with Dor fundoplication for achalasia

  This trial tests POEM against laparoscopic Heller myotomy with Dor fundoplication to see which procedure better helps adults with achalasia.

  Recruiting Minia University · Minya, Minya Governorate · NCT07814027

• Hydrotalcite (Talcid) for relief of rebound acid symptoms after stopping long-term PPI therapy

  We are trying hydrotalcite (Talcid) to see if it relieves rebound acid symptoms in adults who have stopped long-term PPI treatment.

  Recruiting Bayer · Multiple Locations · NCT07291700

• Detecting Barrett's Esophagus in Patients Without GERD Symptoms

  This study is testing a new way to find Barrett's esophagus in people who don’t have GERD symptoms by using a simple capsule test instead of the usual endoscopy.

  Recruiting at 5 sites Case Comprehensive Cancer Center · Aurora, Colorado and 4 other locations · NCT06687603

• Transpyloric versus gastric feeding for premature infants with bronchopulmonary dysplasia

  This trial will see if feeding premature infants with bronchopulmonary dysplasia directly into the small intestine (transpyloric) versus into the stomach reduces reflux and episodes of low oxygen.

  Recruiting at 3 sites Children's Hospital of Philadelphia · Palo Alto, California and 3 other locations · NCT06534359

• Measuring mucosal impedance to diagnose gastroesophageal reflux disease

  This study is testing a new way to measure the lining of the esophagus to see if it can help diagnose gastroesophageal reflux disease (GERD) better in patients who haven't improved with standard medications.

  Recruiting Hospital de Clinicas José de San Martín · Buenos Aires · NCT06339801

• Cow's-milk-protein-free diet versus omeprazole for reflux in infants

  This test compares a cow's-milk-protein-free diet to the medicine omeprazole for infants under one year who have troublesome gastroesophageal reflux.

  Recruiting Phase 4 Odense University Hospital · Aabenraa, Region Syddanmark and 2 other locations · NCT06255886

• Understanding gastrointestinal disorders in at-risk infants

  This study looks at how common gut problems are in at-risk infants, like those born early or who had trouble at birth, to see how these issues affect their growth and health in the first two years of life.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT06031025

• Breath testing for small intestinal bacterial overgrowth after proton pump inhibitors

  This study is testing if people with gastroesophageal reflux symptoms who have taken proton pump inhibitors have a higher chance of having small intestinal bacterial overgrowth by using breath tests.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT05976165

• Reducing reflux after sleeve gastrectomy using gastropexy

  This study is testing if a procedure called gastropexy can help reduce reflux symptoms in very overweight patients who are having sleeve gastrectomy surgery.

  Recruiting at 3 sites Helse Forde · Førde and 3 other locations · NCT05704348

• Using a band to reduce nighttime reflux symptoms

  This study is testing if a special band worn around the throat can help people with GERD feel better at night and reduce their reflux symptoms.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05697393

• Repairing the esophagus during weight loss surgery for patients with a weak valve

  This study tests if fixing a hiatal hernia during weight loss surgery can help people with a weak valve have fewer problems like acid reflux and esophagus damage after their surgery.

  Recruiting at 2 sites Sengkang General Hospital · Singapore and 1 other locations · NCT05330910

• Assessing esophageal motility after partial fundoplication for reflux

  This study is testing how a surgery for acid reflux affects the way food moves through the esophagus in patients who have had or will have the procedure.

  Recruiting Spital Limmattal Schlieren · Schlieren, Canton of Zurich · NCT05132816

• Using domperidone to help young people with severe stomach issues

  This study is testing if the medication domperidone can help young people aged 12 to 21 with severe stomach problems that haven't improved with other treatments.

  Recruiting Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT04699591

• Predicting gastroesophageal reflux after sleeve gastrectomy

  This study is trying to find out what factors might lead to gastroesophageal reflux disease (GERD) in people after they have sleeve gastrectomy surgery.

  Recruiting Mayo Clinic · Orlando, Florida and 1 other locations · NCT04411823

• Project to improve detection of Barrett's Esophagus and related neoplasia

  This study is testing new ways to better detect Barrett's esophagus and early signs of cancer to help improve care for patients with this condition.

  Recruiting Midwest Veterans' Biomedical Research Foundation · Kansas City, Missouri · NCT00590239

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Omega Partial Fundoplication: a new implant to treat GERD

  A new implantable device called the Omega Partial Fundoplication (Ω-PF) aims to simplify surgery for GERD and improve quality of life for adults with reflux who don’t respond well to medicines.

  NIH research Aplos Medical INC · Eden Prairie, United States · NIH-11409770

• Understanding how reflux harms lung transplants and what to do about it

  Researchers are studying how stomach contents leaking into the lungs affects transplant health and how to stop or slow this damage.

  NIH research Northwestern University · Chicago, United States · NIH-11394640

• How acid reflux might harm lung transplants

  This project explores whether stomach acid or tiny amounts of stomach contents that reach the lungs cause early and long-term problems in people who have had lung transplants.

  NIH research Northwestern University · Chicago, United States · NIH-11193903

• How chronic acid reflux may cause harmful protein clumps that lead to esophagus cancer

  This project tests whether long-term acid reflux causes damaging protein clumps in esophagus cells of people with chronic GERD or Barrett's esophagus that can help drive esophageal cancer.

  NIH research Miami VA Health Care System · Miami, United States · NIH-11185178

• Understanding how acid reflux affects lung transplant outcomes

  This study is looking at how stomach acid can affect lung transplant patients and cause problems with their new lungs, hoping to find better ways to help these patients feel better and improve their treatment options.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10933924

• Creating a mobile app to help patients with acid reflux ask better questions about their health

  This study is creating a friendly mobile app called 'Esophagus-Qs' to help people with GERD ask the right questions during doctor visits, so they can feel more confident and involved in managing their health.

  NIH research Stanford University · Stanford, United States · NIH-10916452

Related topics

Quick answers

How many Gastroesophageal Reflux clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (7 trials), Denmark (1 trial), Norway (1 trial), Singapore (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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